ArticleIranian journal of pharmaceutical research : IJPR2013
Triterpenes and Steroids from Euphorbia denticulata Lam. With Anti-Herpes Symplex Virus Activity.
Article in Iranian journal of pharmaceutical research : IJPR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis ofPlants (Basel, Switzerland) · 2023Article
- New Cytotoxic Premyrsinane-Type Diterpenes fromIranian journal of pharmaceutical research : IJPR · 2022Article
- Effects of Plant Metabolites on the Growth of COVID-19 (Coronavirus Disease-19) Including Omicron Strain.Cureus · 2022Review
- Conventional Medicinal Uses, Phytoconstituents, and Biological Activities ofAdvances in pharmacological and pharmaceutical sciences · 2022Review
- Anti-viral triterpenes: a review.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
- High cytotoxicity of betulin towards fish and murine fibroblasts: Is betulin safe for nonneoplastic cells?BMC veterinary research · 2021Article
- Anticancer Potential of Betulonic Acid Derivatives.International journal of molecular sciences · 2021Review
- Anti-viral activity ofInternational journal of ophthalmology · 2021Article
- Sterols and Triterpenes: Antiviral Potential Supported by In-Silico Analysis.Plants (Basel, Switzerland) · 2020Review
- Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules.Molecules (Basel, Switzerland) · 2020Review
- Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic.Frontiers in medicine · 2020Review
- Attenuation of inflammation in streptozotocin-induced diabetic rabbits byChinese herbal medicines · 2020Article
- Review
- Euphosantianane E-G: Three New Premyrsinane Type Diterpenoids fromMolecules (Basel, Switzerland) · 2019Article
- Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targetsOncotarget · 2018Article
- A New Taraxastane Triterpene fromIranian journal of pharmaceutical research : IJPR · 2018Article
- Triterpene Constituents ofIranian journal of pharmaceutical research : IJPR · 2016Article
- Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives.Molecules (Basel, Switzerland) · 2015Article
- The Triterpenoid Betulin Protects against the Neuromuscular Effects of Bothrops jararacussu Snake Venom In Vivo.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1.Iranian journal of pharmaceutical research : IJPR · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23E-ene-3β,25- diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The structure of these compounds was elucidated by NMR and mass spectroscopic methods. The MTS assay was used to determine the toxicity and antiviral activity of betulin and (3β,23E)-cycloarta-23-ene-3,25-diol. Betulin showed anti-HSV-1 activity with EC50 value of 84.37±0.02 μg/mL, and toxicity on normal vero cells with CC50 value of 660.718±0.072 μg/mL. (3β,23E)-Cycloarta-23-ene-3,25-diol showed antiviral effect with EC50 value of 86.63±0.03 μg/mL, and toxicity with CC50 value of 1089.21±0.25 μg/mL. The results revealed that these two compounds have the antiviral activity far below the CC50 value with selectivity index (CC50/EC50) values of 7.83, and 12.57, respectively.
Indexed as
Identifiers
24523756PMC3920720W2134420769What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.