ArticleIranian journal of pharmaceutical research : IJPR2013
Formulation and In-vitro Evaluation of Tretinoin Microemulsion as a Potential Carrier for Dermal Drug Delivery.
Article in Iranian journal of pharmaceutical research : IJPR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma.Pharmaceutics · 2023Article
- Release of Tretinoin Solubilized in Microemulsion from Carbopol and Xanthan Gel: In Vitro versus Ex Vivo Permeation Study.Polymers · 2023Article
- Nanoemulsions as novel nanocarrieres for drug delivery across the skin: In-vitro, in-vivo evaluation of miconazole nanoemulsions for treatment ofDesigned monomers and polymers · 2021Article
- Topical Delivery of Geranium/Calendula Essential Oil-Entrapped Ethanolic Lipid Vesicular Cream to Combat Skin Aging.BioMed research international · 2021Article
- Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology.Nanomaterials (Basel, Switzerland) · 2020Review
- A Wound Healing Formulation Based on Iranian Traditional Medicine and Its HPTLC Fingerprint.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Formulation of a Traditionally Used Polyherbal Product for Burn Healing and HPTLC Fingerprinting of Its Phenolic Contents.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Development and Evaluation of Thymol Microparticles Using Cellulose Derivatives as Controlled Release Dosage form.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Development of microemulsion containing thai herbal remedy extract for treatment of urticaria.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. In released studies, static Franz diffusion cells mounted with dialysis membrane were used. Sampling was conducted every 3 h at room temperature over a period of 24 h. The amount of released drug was measured with UV-spectrophotometer and the percentage of drug released was calculated. Based on the results obtained, the oil phase concentration had a proportional effect on particle size which can consequently influence on drug release. The particle size and the amount of released drug were affected by the applied surfactants. The components of the optimized microemulsion formulation were 15% olive oil, 12% propylene glycol (as co-surfactant), 33% Tween(®)80 (as surfactant) and 40% distilled water, which was tested for viscosity and rheological behavior. The prepared tretinoin microemulsion showed pseudoplastic-thixotropic behavior. The profile of drug release follows zero order kinetics. The optimized tretinoin microemulsion showed enhanced in-vitro release profile compared to the commercial gels and creams.
Indexed as
Identifiers
24523740PMC3920698What OpenQuestion holds
Registered trials
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