ArticleFrontiers in behavioral neuroscience2014
Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.Journal of affective disorders reports · 2026Article
- Contextual Fear Conditioning Selectively Increases Levels of Arc and c-Fos Proteins in the Dorsal, but not the Ventral Hippocampus.Neurochemical research · 2026Article
- LIMK1 Deficiency Disrupts Hippocampal-Cortical Memory Consolidation and Attenuates Trauma-Induced PTSD-like Behavior.Biology · 2025Article
- Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Neural correlates of PTSD in women with childhood sexual abuse with and without PTSD and response to paroxetine treatment: A placebo-controlled, double-blind trial.Journal of affective disorders reports · 2023Article
- Adverse Childhood Events, Post-Traumatic Stress Disorder, Infectious Encephalopathies and Immune-Mediated Disease.Healthcare (Basel, Switzerland) · 2022Review
- Cardinal role of the environment in stress induced changes across life stages and generations.Neuroscience and biobehavioral reviews · 2021Review
- Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neurofascin Knock Down in the Basolateral Amygdala Mediates Resilience of Memory and Plasticity in the Dorsal Dentate Gyrus Under Stress.Molecular neurobiology · 2018Article
- Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala.Frontiers in neuroscience · 2018Article
- Aggressiveness, violence, homicidality, homicide, and Lyme disease.Neuropsychiatric disease and treatment · 2018Article
- Pre-trauma Methylphenidate in rats reduces PTSD-like reactions one month later.Translational psychiatry · 2017Article
- Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission.Neuroscience and biobehavioral reviews · 2016Review
- A novel approach to PTSD modeling in rats reveals alternating patterns of limbic activity in different types of stress reaction.Molecular psychiatry · 2016Article
- Animal models for posttraumatic stress disorder: An overview of what is used in research.World journal of psychiatry · 2015Review
- Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder.Molecular brain · 2015Article
- Animal models of post-traumatic stress disorder and recent neurobiological insights.Behavioural pharmacology · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recollection of emotional memories is attributed in part to the activation of the amygdala and the hippocampus. Recent hypothesis suggests a pivotal role for the ventral hippocampus (VH) in traumatic stress processing and emotional memory retrieval. Persistent re-experiencing and intrusive recollections are core symptoms in acute and posttraumatic stress disorders (ASD; PTSD). Such intrusive recollections are often triggered by reminders associated with the trauma. We examined the impact of exposure to a trauma reminder (under water trauma (UWT)) on the activation of the basolateral amygdala (BLA), dorsal and VH. Rats were exposed to UWT and 24 h later were re-exposed to the context of the trauma. Phosphorylation of the extracellular signal-regulated kinase (ERK) was used as a marker for level of activation of these regions. Significant increase in ERK activation was found in the VH and BLA. Such pattern of activation was not found in animals exposed only to the trauma or in animals exposed only to the trauma reminder. Additionally, the dissociative pattern of activation of the VH sub-regions positively correlated with the activation of the BLA. Our findings suggest a specific pattern of neural activation during recollection of a trauma reminder, with a unique contribution of the VH. Measured 24 h after the exposure to the traumatic experience, the current findings relate to relatively early stages of traumatic memory consolidation. Understanding the neural mechanisms underlying these initial stages may contribute to developing intervention strategies that could reduce the risk of eventually developing PTSD.
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