Evidence map›Paper›PMID 24523659›Full record

ArticleTheScientificWorldJournal2013

High-dose amoxicillin with clavulanate for the treatment of acute otitis media in children.

Chia-Huei Chu, Mao-Che Wang, Liang-Yu Lin, Tzong-Yang Tu, Chii-Yuan Huang, Wen-Huei Liao, Ching-Yin Ho, An-Suey Shiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. New insights into the treatment of acute otitis media.Expert review of anti-infective therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chia-Huei ChuDepartment of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
Mao-Che WangDepartment of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
Liang-Yu LinDivision of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Medicine, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11172, Taiwan ; Institute of Pharmacology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
Tzong-Yang TuDepartment of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
Chii-Yuan HuangDepartment of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
Wen-Huei LiaoDepartment of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
Ching-Yin HoDepartment of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.ORCID 0000-0001-5487-2531
An-Suey ShiaoDepartment of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study uses the acute otitis media clinical practice guideline proposed in 2004 as a reference to evaluate whether antibiotics doses that are in line with the recommendations lead to better prognosis. The study also attempts to clarify possible factors that influence the outcome. STUDY

designRetrospective cohort study. SUBJECTS AND

methodsA total of 400 children with acute otitis media were enrolled. The dosage of amoxicillin was considered to be appropriate when in accord with clinical practice guidelines, that is, 80-90 mg/kg/day. The outcome was defined according to the description of tympanic membrane on medical records. Multivariate logistic regression was used to analyze the relationship between antibiotic dosage and prognosis after adjusting for baseline factors.

resultsThe majority of prescriptions were under dosage (89.1%) but it was not noticeably associated with outcome (P = 0.41). The correlation between under dosage and poor prognosis was significant in children below 20 kg with bilateral acute otitis media (odds ratio 1.63; 95% CI 1.02-2.59, P = 0.04).

conclusionTreating acute otitis media in children, high-dose amoxicillin with clavulanate as recommended in the clinical practice guideline was superior to conventional doses only in children under 20 kg with bilateral diseases.

Indexed as

Acute DiseaseAmoxicillinChildChild, PreschoolClavulanic AcidDrug Therapy, CombinationFemaleHumansMaleOtitis MediaRetrospective StudiesRisk FactorsSeasonsTreatment OutcomeAmoxicillinClavulanic Acid

Identifiers

PMID24523659
PMCPMC3910352
OpenAlexW2048067680

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.