Evidence map›Paper›PMID 24523654›Full record

ArticleTheScientificWorldJournal2014

In vitro vitamin K3 effect on conjunctival fibroblast migration and proliferation.

I Pinilla, L B Izaguirre, F J Gonzalvo, E Piazuelo, M A Garcia-Gonzalez, A I Sanchez-Cano, F Sopeña

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

I PinillaDepartment of Ophthalmology, Lozano Blesa University Hospital, C/San Juan Bosco 15, 50009 Zaragoza, Spain ; Aragon Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain.
L B IzaguirreDepartment of Ophthalmology, Hospital García Orcoyen, Navarra, 31200 Estella, Spain.
F J GonzalvoDepartment of Ophthalmology, Complejo Hospitalario de Navarra, Navarra, 31008 Pamplona, Spain.
E PiazueloAragon Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain.
M A Garcia-GonzalezAragon Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain.
A I Sanchez-CanoAragon Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain ; Department of Applied Physics, Zaragoza University, 50009 Zaragoza, Spain.
F SopeñaAragon Institute of Health Sciences (IIS Aragon), 50009 Zaragoza, Spain ; Department of Gastroenterology, Lozano Blesa University Hospital, C/San Juan Bosco 15, 50009 Zaragoza, Spain.
Hospital Clínico Universitario Lozano Blesa · ESInstituto de Investigación Sanitaria Aragón · ESComplejo Hospitalario de Navarra · ESUniversidad de Zaragoza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the dose effect of vitamin K3 on wound healing mechanisms.

methodsConjunctival fibroblasts were incubated for 24 hours. An artificial wound was made and the cells were incubated with fresh medium plus doses of vitamin K3 to be tested. Wound repair was monitored at 0, 18, 24, and 48 hours. Proliferation was measured in actively dividing cells by [(3)H]thymidine uptake. Six different groups were tested: group 1/no drugs added, group 2/ethanol 0.1%, group 3/vitamin K3 1 mg/L, group 4/vitamin K3 2 mg/L, group 5/vitamin K3 4 mg/L, and group 6/vitamin K3 6 mg/L. Each experiment was carried out in triplicate and 4 times.

resultsThere were no differences among groups at the initial time. In vitro wound repair was slower in groups 4, 5, and 6. There were no differences between control and ethanol groups and between control and vitamin K3 1 mg/L groups. Fibroblast mitogenic activity was statistically decreased in all vitamin K groups; statistical differences were found among vitamin K3 1 mg/mL and higher doses too. In groups 5 and 6, cellular toxicity was presented.

conclusionsVitamin K3 is able to inhibit fibroblast proliferation. Vitamin K3 2 mg/L or higher doses inhibit wound healing repair, exhibiting cellular toxicity at 4 and 6 mg/L.

Indexed as

Cell MovementCell ProliferationCells, CulturedConjunctivaFibroblastsHumansVitamin K 3Vitamin K 3

Identifiers

PMID24523654
PMCPMC3910386
OpenAlexW2026141886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.