ArticleCurrent oncology (Toronto, Ont.)2014
Diagnostic value of preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 in colorectal cancer.
Article in Current oncology (Toronto, Ont.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Prognostic value of pretreatment serum carbohydrate antigen 19-9 level in patients with colorectal cancer: A meta-analysis.PloS one · 2017Pooled it
- FDG-avid pulse granulomas mimicking peritoneal metastases in colorectal cancer: a case report.Journal of surgical case reports · 2026Article
- Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Early-Onset Colorectal Cancer.Journal of gastrointestinal cancer · 2025Article
- A machine learning-based prediction model for colorectal liver metastasis.Clinical and experimental medicine · 2025Article
- A nomogram model for predicting lymph node metastasis of rectal cancer by combining preoperative magnetic resonance imaging signs and tumour markers.Polish journal of radiology · 2025Article
- Construction of a nomogram based on clinicopathologic features to predict the likelihood of No. 253 lymph node metastasis in rectal cancer patients.Langenbeck's archives of surgery · 2024Article
- Helicobacter Pylori Infection as the Predominant High-Risk Factor for Gastric Cancer Recurrence Post-Gastrectomy: An 8-Year Multicenter Retrospective Study.International journal of general medicine · 2024Article
- Article
- Intestinal tuberculosis masquerading as carcinoma colon: a case report of diagnostic quandary in low-resource setting.Journal of surgical case reports · 2022Article
- Holding Multiple Identities: a Personal Narrative of Young Onset Colorectal Cancer.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020Article
- The Importance of Determining Preoperative Serum Concentration of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen in Assessing the Progression of Colorectal Cancer.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2020Article
- THE Role of Preoperative carcinoembryonic antigen in recurrence of resectable colorectal carcinoma.Acta clinica Croatica · 2020Article
- Prognostic significance of serum carcinoembryonic antigen and squamous cell carcinoma antigen in patients with esophageal squamous cell carcinoma undergoing radical esophagectomy.Translational cancer research · 2020Article
- Machine Learning Algorithms for Predicting the Recurrence of Stage IV Colorectal Cancer After Tumor Resection.Scientific reports · 2020Article
- Multiplex screening of 275 plasma protein biomarkers to identify a signature for early detection of colorectal cancer.Molecular oncology · 2020Article
- The clinical impact of miRNA34a and P53 gene expression in colon cancer.Biochemistry and biophysics reports · 2018Article
- Clinical significance of the globulin-to-albumin ratio for prediction of postoperative survival in patients with colorectal cancer.Annals of gastroenterological surgery · 2018Article
- Serum CNPY2 isoform 2 represents a novel biomarker for early detection of colorectal cancer.Aging · 2018Article
- HbA1c is Positively Associated with Serum Carcinoembryonic Antigen (CEA) in Patients with Diabetes: A Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2018Article
- Development of a novel biomarker model for predicting preoperative lymph node metastatic extent in esophageal squamous cell carcinomaOncotarget · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the first introduction of tumour markers, their usefulness for diagnosis has been a challenging question. The aim of the present prospective study was to investigate, in colorectal cancer patients, the relationship between preoperative tumour marker concentrations and various clinical variables.
methodsThe study prospectively enrolled 131 consecutive patients with a confirmed diagnosis of colorectal carcinoma and 131 age- and sex-matched control subjects with no malignancy. The relationships of the tumour markers carcinoembryonic antigen (cea) and carbohydrate antigen (ca) 19-9 with disease stage, tumour differentiation (grade), mucus production, liver function tests, T stage, N stage, M stage were investigated.
resultsSerum concentrations of cea were significantly higher in the patient group than in the control group (p = 0.001); they were also significantly higher in stage iii (p = 0.018) and iv disease (p = 0.001) than in stage i. Serum concentrations of cea were significantly elevated in the presence of spread to lymph nodes (p = 0.005) in the patient group. Levels of both tumour markers were significantly elevated in the presence of distant metastasis in the patient group (p = 0.005 for cea; p = 0.004 for ca 19-9).
conclusionsPreoperative levels of cea and ca 19-9 might provide an estimate of lymph node invasion and distant metastasis in colorectal cancer patients.
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