Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Nonlinear dose-dependent impact of D1 receptor activation on motor cortex plasticity in humans.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review.Journal of psychiatry & neuroscience : JPNPooled it
- Optimizing tDCS cognitive outcomes in schizophrenia: the role of dopaminergic tone and antipsychotic load.Translational psychiatry · 2026Trial
- NMDA receptor involvement in dopaminergic modulation of neuroplasticity induced by paired associative stimulation.The international journal of neuropsychopharmacology · 2025Trial
- Contribution of Glutamatergic and GABAergic Mechanisms to the Plasticity-Modulating Effects of Dopamine in the Human Motor Cortex.Human brain mapping · 2025Trial
- Association between tDCS computational modeling and clinical outcomes in depression: data from the ELECT-TDCS trial.European archives of psychiatry and clinical neuroscience · 2021Trial
- Hypericum perforatum extract modulates cortical plasticity in humans.Psychopharmacology · 2018Trial
- Chronic Enhancement of Serotonin Facilitates Excitatory Transcranial Direct Current Stimulation-Induced Neuroplasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Effects of L-Dopa and pramipexole on plasticity induced by QPS in human motor cortex.Journal of neural transmission (Vienna, Austria : 1996) · 2015Trial
- Dopamine Alters the Effect of Brain Stimulation on Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortical dopamine D5 receptors regulate neuronal circuit oscillatory activity and memory in rats.CNS neuroscience & therapeutics · 2023Article
- A PAM of the αCurrent research in pharmacology and drug discovery · 2023Article
- NMDA receptor-related mechanisms of dopaminergic modulation of tDCS-induced neuroplasticity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Direct current stimulation modulates gene expression in isolated astrocytes with implications for glia-mediated plasticity.Scientific reports · 2022Article
- Dosage-Dependent Impact of Acute Serotonin Enhancement on Transcranial Direct Current Stimulation Effects.The international journal of neuropsychopharmacology · 2021Article
- Noradrenergic Enhancement of Motor Learning, Attention, and Working Memory in Humans.The international journal of neuropsychopharmacology · 2021Article
- Inhibitory Effect of Apomorphine on Focal and Nonfocal Plasticity in the Human Motor Cortex.Pharmaceutics · 2021Article
- Motor cortical excitability behavior in chronic spinal cord injury neuropathic pain individuals submitted to transcranial direct current stimulation-case reports.Spinal cord series and cases · 2020Article
- The COMT ValThe European journal of neuroscience · 2019Article
- Nicotine modulates human brain plasticity via calcium-dependent mechanisms.The Journal of physiology · 2018Article
- Studying and modifying brain function with non-invasive brain stimulation.Nature neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuromodulator dopamine plays an important role in synaptic plasticity. The effects are determined by receptor subtype specificity, concentration level, and the kind of neuroplasticity induced. D1-like receptors have been proposed to be involved in cognitive processes via their impact on plasticity. Cognitive studies in humans and animals revealed a dosage-dependent effect of D1-like receptor activation on task performance. In humans, D1-like receptor activation re-establishes plasticity under D2 receptor block. However, a dosage-dependent effect has not been explored so far. To determine the impact of the amount of D1-like receptor activation on neuroplasticity in humans, we combined sulpiride, a selective D2 receptor antagonist, with the dopamine precursor l-DOPA (25, 100, and 200 mg) or applied placebo medication. The impact on plasticity induced by anodal and cathodal transcranial direct current stimulation (tDCS) was compared with the impact on plasticity induced by excitatory and inhibitory paired associative stimulation (PAS) at the primary motor cortex of healthy humans. Stimulation-generated cortical excitability alterations were monitored by transcranial magnetic stimulation-induced motor-evoked potential amplitudes. D1-like receptor activation produced an inverted U-shaped dose-response curve on plasticity induced by both facilitatory tDCS and PAS. For excitability-diminishing tDCS and PAS, aftereffects were abolished or converted trendwise into facilitation. These data extend findings of dose-dependent inverted U-shaped effects of D1 receptor activation on neuroplasticity of the motor cortex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.