Evidence map›Paper›PMID 24523553›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014

Dosage effects of BDNF Val66Met polymorphism on cortical surface area and functional connectivity.

Chao Wang, Yuanchao Zhang, Bing Liu, Haixia Long, Chunshui Yu, Tianzi Jiang

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03843463 (Escitalopram and Language Intervention for Subacute Aphasia), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03843463 phase2recruitingnot on this mapstarted 2021, after this paper: background citation

Escitalopram and Language Intervention for Subacute Aphasia (ELISA)

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2027Enrolled88ConditionsAphasia, StrokeArmsEscitalopram 10mg, Placebo, Computer-delivered naming treatment
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Effects of BDNF ValNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
  9. Review
  10. Review
  11. Article
  12. Effect of Prenatal Exposure to Waterpipe Tobacco Smoke on Learning and Memory of Adult Offspring Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018
    Article
  13. Genetic epistasis regulates amyloid deposition in resilient aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Chao WangKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China, Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China, Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China, and Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
Yuanchao Zhang
Bing Liu
Haixia Long
Chunshui Yu
Tianzi Jiang
Institute of Automation · CNUniversity of Electronic Science and Technology of China · CNChinese Academy of Sciences · CNTianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The single nucleotide polymorphism (SNP) that leads to a valine-to-methionine substitution at codon 66 (Val66Met) in BDNF is correlated with differences in cognitive and memory functions, as well as with several neurological and psychiatric disorders. MRI studies have already shown that this genetic variant contributes to changes in cortical thickness and volume, but whether the Val66Met polymorphism affects the cortical surface area of healthy subjects remains unclear. Here, we used multimodal MRI to study whether this polymorphism would affect the cortical morphology and resting-state functional connectivity of a large sample of healthy Han Chinese human subjects. An SNP-wise general linear model analysis revealed a "dosage effect" of the Met allele, specifically a stepwise increase in cortical surface area of the right anterior insular cortex with increasing numbers of the Met allele. Moreover, we found enhanced functional connectivity between the anterior insular and the dorsolateral prefrontal cortices that was linked with the dosage of the Met allele. In conclusion, these data demonstrated a "dosage effect" of BDNF Val66Met on normal cortical structure and function, suggesting a new path for exploring the mechanisms underlying the effects of genotype on cognition.

Indexed as

Polymorphism, Single NucleotideAdolescentAdultBrain-Derived Neurotrophic FactorCerebral CortexFemaleGene DosageGenotypeHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysReverse Transcriptase Polymerase Chain ReactionYoung AdultBDNF protein, humanBrain-Derived Neurotrophic Factoranterior insulabrain-derived neurotrophic factor (BDNF)functional connectivitysurface area

Identifiers

PMID24523553
PMCPMC6802754
OpenAlexW2030413898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.