ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Deprivation-induced strengthening of presynaptic and postsynaptic inhibitory transmission in layer 4 of visual cortex during the critical period.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 40 citations in OpenAlex.
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- A high-dimensional atlas of parvalbumin interneuron soma morphology in mouse visual and somatosensory cortex.Frontiers in neuroscience · 2026Article
- Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Candidate Key Proteins in Tinnitus-A Bioinformatic Study of Synaptic Transmission in the Inferior Colliculus.International journal of molecular sciences · 2025Article
- Glial Control of Cortical Neuronal Circuit Maturation and Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Basal forebrain cholinergic activity is necessary for upward firing rate homeostasis in the rodent visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Thalamic regulation of a visual critical period and motor behavior.Cell reports · 2023Article
- Electrophysiological properties of layer 2/3 pyramidal neurons in the primary visual cortex of a retinitis pigmentosa mouse model (Frontiers in cellular neuroscience · 2023Article
- A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly.Current opinion in neurobiology · 2022Review
- Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics.Journal of cellular physiology · 2022Article
- Balanced Enhancements of Synaptic Excitation and Inhibition Underlie Developmental Maturation of Receptive Fields in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells.Neuron · 2021Article
- Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision.Frontiers in neural circuits · 2021Article
- Monocular Deprivation Affects Visual Cortex Plasticity Through cPKCγ-Modulated GluR1 Phosphorylation in Mice.Investigative ophthalmology & visual science · 2020Article
- Juvenile Social Isolation Enhances the Activity of Inhibitory Neuronal Circuits in the Medial Prefrontal Cortex.Frontiers in cellular neuroscience · 2020Article
- Review
- Early Sensory Loss Alters the Dendritic Branching and Spine Density of Supragranular Pyramidal Neurons in Rodent Primary Sensory Cortices.Frontiers in neural circuits · 2019Article
- Improved methods for marking active neuron populations.Nature communications · 2018Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Inhibition from fast-spiking (FS) interneurons plays a crucial role in shaping cortical response properties and gating developmental periods of activity-dependent plasticity, yet the expression mechanisms underlying FS inhibitory plasticity remain largely unexplored. In layer 4 of visual cortex (V1), monocular deprivation (MD) induces either depression or potentiation of FS to star pyramidal neuron (FS→SP) synapses, depending on the age of onset (Maffei et al., 2004, 2006). This reversal in the sign (- to +) of plasticity occurs on the cusp of the canonical critical period (CP). To investigate the expression locus behind this switch in sign of inhibitory plasticity, mice underwent MD during the pre-CP [eye-opening to postnatal day (p)17] or CP (p22-p25), and FS→SP synaptic strength within layer 4 was assessed using confocal and immunoelectron microscopy, as well as optogenetic activation of FS cells to probe quantal amplitude at FS→SP synapses. Brief MD before p17 or p25 did not alter the density of FS→SP contacts. However, at the ultrastructural level, FS→SP synapses in deprived hemispheres during the CP, but not the pre-CP or in GAD65 knock-out mice, had larger synapses and increased docked vesicle density compared with synapses from the nondeprived control hemispheres. Moreover, FS→SP evoked miniature IPSCs increased in deprived hemispheres when MD was initiated during the CP, accompanied by an increase in the density of postsynaptic GABAA receptors at FS→SP synapses. These coordinated changes in FS→SP synaptic strength define an expression pathway modulating excitatory output during CP plasticity in visual cortex.
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