ArticleThe Journal of biological chemistry2014
Induction of retinal progenitors and neurons from mammalian Müller glia under defined conditions.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Targeting NF-κB/TLR4/ERK/MYD88 and Caspase-1/IL-1β Pathways by Diacerein in Alleviation of 5-Fluorouracil-Induced Myocardial, Corneal, and Retinal Injury.Cardiovascular toxicology · 2026Article
- Bioengineered human tissue regeneration and repair using endogenous stem cells.Cell reports. Medicine · 2023Article
- Harnessing the Neuroprotective Behaviors of Müller Glia for Retinal Repair.Frontiers in bioscience (Landmark edition) · 2022Review
- Dedifferentiation of radial glia-like cells is observed in in vitro explants of holothurian radial nerve cord.Journal of neuroscience methods · 2021Article
- Activated αScientific reports · 2019Article
- Nanotechnology in regenerative ophthalmology.Advanced drug delivery reviews · 2019Review
- 3D bioprinting of hydrogels for retina cell culturing.Bioprinting (Amsterdam, Netherlands) · 2018Article
- Induced dopaminergic neurons: A new promise for Parkinson's disease.Redox biology · 2017Article
- Which has more stem-cell characteristics: Müller cells or Müller cells derived from in vivo culture in neurospheres?American journal of translational research · 2017Article
- Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinas.Oncotarget · 2016Article
- Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- Stem Cell Therapy for Treatment of Ocular Disorders.Stem cells international · 2016Review
- Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Vision impairment caused by loss of retinal neurons affects millions of people worldwide, and currently, there is no effective treatment. Müller glia of mammalian retina may represent an under-recognized and potential source for regeneration of a wide range of retinal cell types, including retinal ganglion cells and photoreceptors. Here, we demonstrated that mouse Müller glia cells have the capacity to be reprogrammed into the retinal neuronal cell fate and are competent to give rise to photoreceptors under a defined culture condition. Inactivation of p53 released proliferation restriction of Müller glia and significantly enhanced the induction of retinal progenitor from Müller glia in culture. Moreover, following the ocular transplantation, the Müller glia-derived progenitors were differentiated toward the fates of photoreceptors and retinal ganglion cells. Together, these results demonstrate the feasibility of using Müller glia as a potential source for retinal repair and regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.