ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Systemic leptin dose-dependently increases STAT3 phosphorylation within hypothalamic and hindbrain nuclei.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats.American journal of physiology. Endocrinology and metabolism · 2025Article
- Alterations in Adipokine Levels Are Associated with Human Perinatal Anxiety and Depression.Journal of clinical medicine · 2025Article
- Neural circuits regulation of satiation.Appetite · 2024Review
- Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss.American journal of physiology. Endocrinology and metabolism · 2024Review
- Low-dose peripheral leptin infusion produces selective activation of ventromedial hypothalamic and hindbrain STAT3.American journal of physiology. Endocrinology and metabolism · 2023Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- The role of nucleus of the solitary tract glucagon-like peptide-1 and prolactin-releasing peptide neurons in stress: anatomy, physiology and cellular interactions.British journal of pharmacology · 2022Review
- Phosphorylation of STAT3 in hypothalamic nuclei is stimulated by lower doses of leptin than are needed to inhibit food intake.American journal of physiology. Endocrinology and metabolism · 2021Article
- Consuming sucrose solution promotes leptin resistance and site specifically modifies hypothalamic leptin signaling in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.Endocrine reviews · 2021Review
- Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress.Nutrients · 2020Review
- Leptin Sensitizes NTS Neurons to Vagal Input by Increasing Postsynaptic NMDA Receptor Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Glial Endozepines Reverse High-Fat Diet-Induced Obesity by Enhancing Hypothalamic Response to Peripheral Leptin.Molecular neurobiology · 2020Article
- Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and leptin response.Biology of reproduction · 2020Article
- Ghrelin signaling contributes to fasting-induced attenuation of hindbrain neural activation and hypophagic responses to systemic cholecystokinin in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Acute Blockade of PACAP-Dependent Activity in the Ventromedial Nucleus of the Hypothalamus Disrupts Leptin-Induced Behavioral and Molecular Changes in Rats.Neuroendocrinology · 2020Article
- Leptin receptor-expressing neurons in ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions.American journal of physiology. Endocrinology and metabolism · 2019Article
- Review
- Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats.Nutrition & diabetes · 2019Article
- Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus.Molecular neurobiology · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Leptin released peripherally acts within the central nervous system (CNS) to modulate numerous physiological and behavioral functions. Histochemical identification of leptin-responsive CNS cells can reveal the specific cellular phenotypes and neural circuits through which leptin signaling modulates these functions. Leptin signaling elicits phosphorylation of signal transducer and activator of transcription 3 (pSTAT3), making pSTAT3-immunoreactivity (ir) a useful proxy for identifying leptin-responsive cells. Relatively low systemic doses of leptin (i.e., 10-130 μg/kg body wt) are sufficient to decrease food intake, inhibit gastric emptying, and increase sympathetic activity, but there are no histological reports of central pSTAT3-ir following leptin doses within this range. Considering this, we quantified central pSTAT3-ir in rats after intraperitoneal injections of leptin at doses ranging from 50 to 800 μg/kg body wt. Tissue sections were processed to identify pSTAT3-ir alone or in combination with immunolabeling for cocaine- and amphetamine-regulated transcript (CART), glucagon-like peptide-1 (GLP-1), prolactin-releasing peptide (PrRP), or dopamine-β-hydroxylase (DβH). Leptin doses as low as 50, 100, and 200 μg/kg body wt significantly increased the number of pSTAT3-ir cells in the arcuate nucleus of the hypothalamus (ARC), nucleus of the solitary tract (NTS), and ventromedial nucleus of the hypothalamus, respectively, and also led to robust pSTAT3 labeling in neural processes. The differential dose-dependent increases in pSTAT3-ir across brain regions provide new information regarding central leptin sensitivity. Within the ARC, CART-ir and pSTAT3-ir were often colocalized, consistent with evidence of leptin sensitivity in this neural population. Conversely, within the NTS, pSTAT3 only rarely colocalized with PrRP and/or DβH, and never with GLP-1.
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Registered trials
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