ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Obesity and pain: a systematic review.International journal of obesity (2005) · 2020Pooled it
- Risk of Acute Pain in Obese Patients Undergoing Atrial Fibrillation Ablation.Journal of pain research · 2025Article
- The relationship of redox signaling with the risk for atherosclerosis.Frontiers in pharmacology · 2024Review
- Perivascular Adipose Tissue Oxidative Stress in Obesity.Antioxidants (Basel, Switzerland) · 2023Review
- ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance.American journal of physiology. Heart and circulatory physiology · 2022Article
- Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs.PloS one · 2022Article
- Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity.Metabolites · 2021Article
- Overproduction of endothelin-1 impairs glucose tolerance but does not promote visceral adipose tissue inflammation or limit metabolic adaptations to exercise.American journal of physiology. Endocrinology and metabolism · 2019Article
- Increased endothelial shear stress improves insulin-stimulated vasodilatation in skeletal muscle.The Journal of physiology · 2019Article
- Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats.Adipocyte · 2018Article
- Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21.The Journal of endocrinology · 2017Article
- Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets.British journal of pharmacology · 2017Review
- Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats.Scientific reports · 2017Article
- Absence of Endothelial ERα Results in Arterial Remodeling and Decreased Stiffness in Western Diet-Fed Male Mice.Endocrinology · 2017Article
- Habitual physical activity protects against lipopolysaccharide-induced inflammation in mouse adipose tissue.Adipocyte · 2017Article
- Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats.Medicine and science in sports and exercise · 2016Article
- The Gq signalling pathway inhibits brown and beige adipose tissue.Nature communications · 2016Article
- Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs.Obesity (Silver Spring, Md.) · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Adipose tissue (AT)-derived cytokines are proposed to contribute to obesity-associated vascular insulin resistance. We tested the hypothesis that voluntary physical activity and diet restriction-induced maintenance of body weight would both result in decreased AT inflammation and concomitant improvements in insulin-stimulated vascular relaxation in the hyperphagic, obese Otsuka Long-Evans Tokushima fatty (OLETF) rat. Rats (aged 12 wk) were randomly assigned to sedentary (SED; n = 10), wheel running (WR; n = 10), or diet restriction (DR; n = 10; fed 70% of SED) for 8 wk. WR and DR rats exhibited markedly lower adiposity (7.1 ± 0.4 and 15.7 ± 1.1% body fat, respectively) relative to SED (27 ± 1.2% body fat), as well as improved blood lipid profiles and systemic markers of insulin resistance. Reduced adiposity in both WR and DR was associated with decreased AT mRNA expression of inflammatory genes (e.g., MCP-1, TNF-α, and IL-6) and markers of immune cell infiltration (e.g., CD8, CD11c, and F4/80). The extent of these effects were most pronounced in visceral AT compared with subcutaneous and periaortic AT. Markers of inflammation in brown AT were upregulated with WR but not DR. In periaortic AT, WR- and DR-induced reductions in expression and secretion of cytokines were accompanied with a more atheroprotective gene expression profile in the adjacent aortic wall. WR, but not DR, resulted in greater insulin-stimulated relaxation in the aorta; an effect that was, in part, mediated by a decrease in insulin-induced endothelin-1 activation in WR aorta. Collectively, we show in OLETF rats that lower adiposity leads to less AT and aortic inflammation, as well as an exercise-specific improvement in insulin-stimulated vasorelaxation.
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Registered trials
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