ReviewReviews in the neurosciences2014
Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum.
Review in Reviews in the neurosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The prevalence of autism in cerebellar malformations: a systematic review and meta-analysis.Journal of neurodevelopmental disorders · 2026Pooled it
- A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease.Brain : a journal of neurology · 2026Article
- A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children.Frontiers in neuroscience · 2023Review
- Oxidative Stress-Induced Damage to the Developing Hippocampus Is Mediated by GSK3β.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Maternal exposure to the environmental pollutant "BDE-47" impairs the postnatal development of rat cerebellar cortex by modulating neuronal proliferation, synaptogenesis, NGF and BDNF pathways.Histology and histopathology · 2022Article
- Early postnatal irradiation-induced age-dependent changes in adult mouse brain: MRI based characterization.BMC neuroscience · 2021Article
- A unified circuit for social behavior.Neurobiology of learning and memory · 2019Article
- Assessing drug response in engineered brain microenvironments.Brain research bulletin · 2019Review
- A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity.Frontiers in behavioral neuroscience · 2019Article
- Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis.NeuroImage · 2018Article
- Histological Characterization of the Irritative Zones in Focal Cortical Dysplasia Using a Preclinical Rat Model.Frontiers in cellular neuroscience · 2018Article
- Postnatal colonization with human "infant-type" Bifidobacterium species alters behavior of adult gnotobiotic mice.PloS one · 2018Article
- Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A.Translational psychiatry · 2016Article
- Spontaneous activity and functional connectivity in the developing cerebellorubral system.Journal of neurophysiology · 2016Article
- Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos.Toxicology · 2015Article
- Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The therapeutic potential of the cerebellum in schizophrenia.Frontiers in systems neuroscience · 2014Article
- Cellular commitment in the developing cerebellum.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies have advanced our understanding of the role of the cerebellum in non-motor behaviors. Abnormalities in the cerebellar structure have been demonstrated to produce changes in emotional, cognitive, and social behaviors resembling clinical manifestations observed in patients with autism spectrum disorders (ASD) and schizophrenia. Several animal models have been used to evaluate the effects of relevant environmental and genetic risk factors on the cerebellum development and function. However, very few models of ASD and schizophrenia selectively target the cerebellum and/or specific cell types within this structure. In this review, we critically evaluate the strength and weaknesses of these models. We will propose that the future progress in this field will require time- and cell type-specific manipulations of disease-relevant genes, not only selectively in the cerebellum, but also in frontal brain areas connected with the cerebellum. Such information can advance our knowledge of the cerebellar contribution to non-motor behaviors in mental health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.