ArticleHuman brain mapping2014
Longitudinal growth and morphology of the hippocampus through childhood: Impact of prematurity and implications for memory and learning.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Hippocampal growth and function are reduced in the newborn following fetal growth restriction.Brain : a journal of neurology · 2026Article
- A Narrative Review of Neurodevelopmental, Psychiatric, and Behavioral Consequences of Preterm Birth.Cureus · 2025Review
- Automated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: AID-HS.Annals of neurology · 2024Article
- Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood.Developmental science · 2024Article
- Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies.Pediatric research · 2024Review
- Predicting neurodevelopmental outcome in children born very preterm - does neonatal MRI have a role?Pediatric research · 2023Article
- Novel metrics to characterize temporal lobe of very preterm infants on term-equivalent brain MRI.Pediatric research · 2023Article
- Hippocampal volume and cognitive performance in children with congenital heart disease.Pediatric research · 2023Article
- Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment.Brain sciences · 2023Article
- Early life factors and hippocampal functional connectivity in children with overweight/obesity.Pediatric obesity · 2023Article
- Neurobehavioral Phenotype and Dysexecutive Syndrome of Preterm Children: Comorbidity or Trigger? An Update.Children (Basel, Switzerland) · 2022Review
- Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage.Scientific reports · 2021Article
- Racial and socioeconomic disparities in breast milk feedings in US neonatal intensive care units.Pediatric research · 2021Review
- Alteration of the brain methylation landscape following postnatal inflammatory injury in rat pups.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease.Human brain mapping · 2019Article
- Born Too Early and Too Small: Higher Order Cognitive Function and Brain at Risk at Ages 8-16.Frontiers in psychology · 2019Article
- Reduced hippocampal subfield volumes and memory function in school-aged children born preterm with very low birthweight (VLBW).NeuroImage. Clinical · 2019Article
- Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury.NeuroImage. Clinical · 2019Observational
- Hippocampus, Amygdala, and Thalamus Volumes in Very Preterm Children at 8 Years: Neonatal Pain and Genetic Variation.Frontiers in behavioral neuroscience · 2019Article
- Trajectories of brain development in school-age children born preterm with very low birth weight.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The effects of prematurity on hippocampal development through early childhood are largely unknown. The aims of this study were to (1) compare the shape of the very preterm (VPT) hippocampus to that of full-term (FT) children at 7 years of age, and determine if hippocampal shape is associated with memory and learning impairment in VPT children, (2) compare change in shape and volume of the hippocampi from term-equivalent to 7 years of age between VPT and FT children, and determine if development of the hippocampi over time predicts memory and learning impairment in VPT children. T1 and T2 magnetic resonance images were acquired at both term equivalent and 7 years of age in 125 VPT and 25 FT children. Hippocampi were manually segmented and shape was characterized by boundary point distribution models at both time-points. Memory and learning outcomes were measured at 7 years of age. The VPT group demonstrated less hippocampal infolding than the FT group at 7 years. Hippocampal growth between infancy and 7 years was less in the VPT compared with the FT group, but the change in shape was similar between groups. There was little evidence that the measures of hippocampal development were related to memory and learning impairments in the VPT group. This study suggests that the developmental trajectory of the human hippocampus is altered in VPT children, but this does not predict memory and learning impairment. Further research is required to elucidate the mechanisms for memory and learning difficulties in VPT children.
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Registered trials
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