Observational studyJournal of assisted reproduction and genetics2014
Developmental capacity and pregnancy rate of tetrahedral- versus non-tetrahedral-shaped 4-cell stage human embryos.
Observational study in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.Human reproduction (Oxford, England) · 2025Article
- Seeking arrangements: cell contact as a cleavage-stage biomarker.Reproductive biomedicine online · 2024Article
- Zygote Diameter and Total Cytoplasmic Volume as Useful Predictive Tools of Blastocyst Quality.Geburtshilfe und Frauenheilkunde · 2023Article
- Functional substitution of zona pellucida with modified sodium hyaluronate gel in human embryos.Journal of assisted reproduction and genetics · 2022Article
- Is there a better evolutionary outcome in a 4-cell tetrahedron embryo?JBRA assisted reproduction · 2021Article
- Combinatorial Contact Cues Specify Cell Division Orientation by Directing Cortical Myosin Flows.Developmental cell · 2018Article
- Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo.Nature communications · 2018Review
- Developmental capacity and pregnancy rate of tetrahedral- versus non-tetrahedral-shaped 4-cell stage human embryos.Journal of assisted reproduction and genetics · 2014Article
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Abstract
purposeThe arrangement of the blastomeres within the 4-cell stage embryo reflects the orientation of the cleavage planes during the second division. To examine their relevance, the developmental capacity and the pregnancy rate were compared between tetrahedral-shaped and non-tetrahedral-shaped 4-cell stage human embryos.
methodsThe study included 3,546 4-cell stage embryos. The arrangement of the blastomeres at the 4-cell stage was annotated as being tetrahedral or non-tetrahedral on day 2 of preimplantation development. Embryo quality was compared on day 3 and day 5. Pregnancy rates were calculated per single embryo transfer on day 3 or day 5.
resultsIn total, 2,803 4-cell stage embryos (79 %) displayed a tetrahedral arrangement and 743 (21 %) displayed a non-tetrahedral arrangement. Tetrahedral-shaped embryos developed more into high-quality embryos on day 3 (p < 0.001) and day 5 (p = 0.036) and had a higher blastulation rate (p = 0.009). Though, the number of high-quality embryos selected for transfer did not differ between both groups on day 3 (p = 0.167) and day 5 (p ~ 1). Three hundred thirty single embryo transfers were analysed. No significant difference in clinical pregnancy was found between both groups after transfer on day 3 (p = 0.209) and day 5 (p = 0.653).
conclusionsThe arrangement of the blastomeres according to their previous cleavage planes was correlated to the developmental potential of the 4-cell stage embryo up to the blastocyst stage. If embryo transfers are performed on day 3 and day 5 of development using embryos of adequate quality, the blastomere arrangement at the 4-cell stage had no predictable value regarding pregnancy success.
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