ArticleIntensive care medicine2014
Duration of colonization with antimicrobial-resistant bacteria after ICU discharge.
Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dutch guideline for the prevention and control of multidrug-resistant organisms in the hospital setting, 2024 update.Antimicrobial resistance and infection control · 2025Guideline
- Efficacy and safety of fecal microbiota transplantation for decolonization of intestinal multidrug-resistant microorganism carriage: beyondAnnals of medicinePooled it
- Article
- Timing and clinical risk factors for early acquisition of gut pathogen colonization with multidrug resistant organisms in the intensive care unit.Gut pathogens · 2024Article
- Transmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: a modelling study for bloodstream infections.Scientific reports · 2022Article
- Examining the impact of ICU population interaction structure on modeled colonization dynamics of Staphylococcus aureus.PLoS computational biology · 2022Article
- ICU-Associated Gram-Negative Bloodstream Infection: Risk Factors Affecting the Outcome Following the Emergence of Colistin-Resistant Isolates in a Regional Greek Hospital.Antibiotics (Basel, Switzerland) · 2022Article
- Colonization Dynamics of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Transmission Dynamics of Clostridioides difficile in 2 High-Acuity Hospital Units.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: A Narrative Review.Microorganisms · 2020Review
- Colonization profile and duration by multi-resistant organisms in a prospective cohort of newborns after hospital discharge.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Determining the clinical significance of co-colonization of vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in the intestinal tracts of patients in intensive care units: a case-control study.Annals of clinical microbiology and antimicrobials · 2019Article
- Mathematical modelling to study the horizontal transfer of antimicrobial resistance genes in bacteria: current state of the field and recommendations.Journal of the Royal Society, Interface · 2019Article
- The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions.Open forum infectious diseases · 2019Article
- Close proximity interactions support transmission of ESBL-K. pneumoniae but not ESBL-E. coli in healthcare settings.PLoS computational biology · 2019Article
- The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant Organisms.The American journal of the medical sciences · 2018Article
- Carriage of antibiotic-resistant Gram-negative bacteria after discontinuation of selective decontamination of the digestive tract (SDD) or selective oropharyngeal decontamination (SOD).Critical care (London, England) · 2018Observational
- Extended models for nosocomial infection: parameter estimation and model selection.Mathematical medicine and biology : a journal of the IMA · 2018Article
- Time to acquire and lose carriership of ESBL/pAmpC producing E. coli in humans in the Netherlands.PloS one · 2018Article
- Gut colonization with vancomycin-resistantGut pathogens · 2018Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeReadmission of patients colonized with antimicrobial-resistant bacteria (AMRB) is important in the nosocomial dynamics of AMRB. We assessed the duration of colonization after discharge from the intensive care unit (ICU) with highly resistant Enterobacteriaceae (HRE), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant enterococci (VRE).
methodsData were obtained from a cluster-randomized trial in 13 ICUs in 8 European countries (MOSAR-ICU trial, 2008-2011). All patients were screened on admission and twice weekly for AMRB. All patients colonized with HRE, MRSA, or VRE and readmitted to the same ICU during the study period were included in the current analysis. Time between discharge and readmission was calculated, and the colonization status at readmission was assessed. Because of interval-censored data, a maximum likelihood analysis was used to calculate the survival function, taking censoring into account. A nonparametric two-sample test was used to test for differences in the survival curves.
resultsThe MOSAR-ICU trial included 14,390 patients, and a total of 64,997 cultures were taken from 8,974 patients admitted for at least 3 days. One hundred twenty-five unique patients had 141 episodes with AMRB colonization and at least 1 readmission. Thirty-two patients were colonized with two or more AMRBs. Median times until clearance were 4.8 months for all AMRB together, 1.4 months for HRE, <1 month for MRSA, and 1.5 months for VRE. There were no significant differences between the survival curves.
conclusionFifty percent of the patients had lost colonization when readmitted 2 or more months after previous ICU discharge.
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