ReviewJournal of anesthesia2014
Epidural anesthesia and analgesia in the neonate: a review of current evidences.
Review in Journal of anesthesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Efficacy and Safety of Wound Catheter Infusion with Ropivacaine After Abdominal Surgery in Children Aged < 1 Year: A Randomized Controlled Trial.Paediatric drugs · 2025Trial
- Continuous local anaesthetic wound infusion of bupivacaine for postoperative analgesia in neonates: a randomised control trial (CANWIN Study).BMJ paediatrics open · 2022Trial
- Caudal-Threaded Versus Direct Lumbar/Thoracic Epidural Catheters in Small-Weight Infants-A Single-Center Retrospective Observational Study.Children (Basel, Switzerland) · 2026Article
- Article
- Article
- Association of anesthesia type with prolonged postoperative intubation in neonates undergoing inguinal hernia repair.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Postoperative Analgesia in Neonates and Infants Using Epidural Chloroprocaine and Clonidine.Journal of pain research · 2020Article
- Managing Procedural Pain in the Neonate Using an Opioid-sparing Approach.Clinical therapeutics · 2019Review
- Effects of different methods of anesthesia and analgesia on immune function and serum tumor marker levels in critically ill patients.Experimental and therapeutic medicine · 2017Article
- Regional block via continuous caudal infusion as sole anesthetic for inguinal hernia repair in conscious neonates.Pediatric surgery international · 2017Article
- Neural-Dural Transition at the Thoracic and Lumbar Spinal Nerve Roots: A Histological Study of Human Late-Stage Fetuses.BioMed research international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of single shot spinal anesthesia has been established in ex-premature infants at risk of apnea. However, use of epidural anesthesia in neonates is on the rise. In this systematic analysis, we have reviewed the current evidence on the safety and efficacy of the use of single shot and continuous epidural anesthesia/analgesia in neonates. Current clinical practice is guided by evidence based mostly on non-randomized studies, prospective/retrospective case series and surveys. Single shot caudal blockade as a sole technique has been used in neonates mainly for inguinal hernia repair and circumcision. Use of continuous epidural anesthesia through the caudal route or caudo-thoracic advancement of the catheter for major thoracic and abdominal surgery offers good perioperative analgesia. Other observed benefits are early extubation, attenuation of stress response, early return of bowel function and reduction of general anesthesia-related postoperative complications. However, risk of procedure-related and drug-related complications to the developing neural structure remains a serious concern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.