SynthesisJournal of neuro-oncology2014
End-of-life symptoms and care in patients with primary malignant brain tumors: a systematic literature review.
Synthesis in Journal of neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Defining end-of-life in glioblastoma multiforme: a systematic review.Journal of neuro-oncology · 2025Pooled it
- Palliative care and end-of-life care in adults with malignant brain tumors.Neuro-oncology · 2023Pooled it
- Assessment of the role and effectiveness of nurse-led multimodal intervention in the rehabilitation of dysphagia in patients with brain tumors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Forecasting the risk of early death among patients suffering from lung cancer with brain metastasis after radiotherapy using interpretable machine learning: a study based on the SEER database.Journal of thoracic disease · 2026Article
- Pain at the end of life in patients with cancer: a population-based study on prevalence, relief, and the role of pain assessment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Survival Patterns and Mortality Causes in Patients with Invasive Ependymoma: A Retrospective Cohort Analysis from 2000 to 2019.Medical sciences (Basel, Switzerland) · 2025Article
- The impact of palliative care contact on the use of hospital resources at the end of life for brain tumor patients; a nationwide register-based cohort study.Journal of neuro-oncology · 2025Article
- Prospective assessment of end-of-life symptoms and quality of life in patients with high-grade glioma.Neuro-oncology practice · 2024Article
- Current status of advance care planning, palliative care consultation, and end-of-life care in patients with glioblastoma in South Korea.The oncologist · 2024Article
- Trajectories of Activities of Daily Living in the Last Eight Weeks of Life Among Patients With Terminal Cancer in a Palliative Care Unit: A Retrospective Study.Palliative medicine reports · 2024Article
- Incidence of dysphagia requiring medical attention in various types of cancers: A nationwide population-based cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Optimal care of people with brain cancer in the emergency department: A cross-sectional survey of outpatient perceptions.Asia-Pacific journal of oncology nursing · 2023Article
- A Review on the Application of Hospice Care in Patients with Advanced Cancer.Patient preference and adherence · 2023Review
- Brain Tumor Rehabilitation: Symptoms, Complications, and Treatment Strategy.Brain & NeuroRehabilitation · 2022Review
- Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma.Current oncology reports · 2022Review
- Adolescent and young adult brain tumors: current topics and review.International journal of clinical oncology · 2022Review
- Neuro-oncology and supportive care: the role of the neurologist.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Palliative care for patients with glioma: A recent scientometric analysis of the Web of Science in 2022.Frontiers in oncology · 2022Article
- Aggressiveness of care at end of life in patients with high-grade glioma.Cancer medicine · 2021Article
- Caregiver perceptions of end-of-life care in patients with high-grade glioma.Neuro-oncology practice · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to review the literature on end-of-life symptoms and end-of-life care of adult patients with high-grade glioma (HGG). Despite aggressive treatment, the survival of HGG patients is limited. Symptom management is paramount to maintain maximum quality of life. The goal of this review is to identify the symptoms and the potential needs of brain tumor patients and their caretakers at the end of life. A systematic literature search in PubMed and Cochrane databases was performed for the years 1946 through August 6th, 2013. A total of 6,196 article citations were identified. Based on predefined criteria, 32 articles were retained for detailed examination. Of these 32 articles, only 7 focused on end-of-life symptoms and interventions. All 7 studies were retrospective and focused on inpatients (3), outpatients (2) or both (2). All but one study involved formal hospice. Drowsiness and loss of consciousness was the most common symptom (1-90 %). Poor communication (64 and 90 %), focal neurological deficits (3-62 %), seizures (3-56 %), dysphagia (7-85 %) and headaches (4-62 %) were also frequent. Only 4 studies reported on palliative interventions. Our systematic review shows that HGG patients in the end-of-life phase have a consistently high symptom burden especially during the last days of life. There is no prospective or conclusive literature describing end-of-life symptom management in HGG patients. Prospective research will be needed to further define symptoms and management in the end-of-life phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.