Evidence map›Paper›PMID 24522697›Full record

ArticleScientific reports2014

GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.

Michael E Hildebrand, Graham M Pitcher, Erika K Harding, Hongbin Li, Simon Beggs, Michael W Salter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
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  15. Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael E Hildebrand1] Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada [2] Department of Physiology, University of Toronto, Toronto, ON, Canada [3].
Graham M Pitcher1] Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada [2] Department of Physiology, University of Toronto, Toronto, ON, Canada.
Erika K Harding1] Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada [2] Department of Physiology, University of Toronto, Toronto, ON, Canada.
Hongbin Li1] Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada [2] Department of Physiology, University of Toronto, Toronto, ON, Canada.
Simon Beggs1] Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada [2] Department of Physiology, University of Toronto, Toronto, ON, Canada.
Michael W Salter1] Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada [2] Department of Physiology, University of Toronto, Toronto, ON, Canada.
Hospital for Sick Children · CA

Funding

Canadian Institutes of Health Research MT-12682
6 · The paper itself

Abstract

The composition of the postsynaptic ionotropic receptors that receive presynaptically released transmitter is critical not only for transducing and integrating electrical signals but also for coordinating downstream biochemical signaling pathways. At glutamatergic synapses in the adult CNS an overwhelming body of evidence indicates that the NMDA receptor (NMDAR) component of synaptic responses is dominated by NMDARs containing the GluN2A subunit, while NMDARs containing GluN2B, GluN2C, or GluN2D play minor roles in synaptic transmission. Here, we discovered NMDAR-mediated synaptic responses with characteristics not described elsewhere in the adult CNS. We found that GluN2A-containing receptors contribute little to synaptic NMDAR responses while GluN2B dominates at synapses of lamina I neurons in the adult spinal cord. In addition, we provide evidence for a GluN2D-mediated synaptic NMDAR component in adult lamina I neurons. Strikingly, the charge transfer mediated by GluN2D far exceeds that of GluN2A and is comparable to that of GluN2B. Lamina I forms a distinct output pathway from the spinal pain processing network to the pain networks in the brain. The GluN2D-mediated synaptic responses we have discovered in lamina I neurons provide the molecular underpinning for slow, prolonged and feedforward amplification that is a fundamental characteristic of pain.

Indexed as

AnimalsBenzenesulfonamidesExcitatory Postsynaptic PotentialsHydrazinesIn Vitro TechniquesMalePatch-Clamp TechniquesPhenolsPiperidinesPyrazolesQuinolonesRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSpinal Cord4-(5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acidBenzenesulfonamidesHydrazinesNR2B NMDA receptorNR2D NMDA receptorPhenolsPiperidinesPyrazolesQuinolonesReceptors, AMPAReceptors, N-Methyl-D-AspartateRo 25-6981SulfonamidesTCN 201

Identifiers

PMID24522697
PMCPMC3923208
OpenAlexW2029969214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.