Evidence map›Paper›PMID 24522546›Full record

ArticleScientific reports2014

Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition.

Erwin Reiling, Ewoud N Speksnijder, Amanda C M Pronk, Sjoerd A A van den Berg, Silvia J W Neggers, Ilma Rietbroek, Harry van Steeg, Martijn E T Dollé

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Different Roles ofInternational journal of general medicine · 2021
    Article
  2. p53 Functions in Adipose Tissue Metabolism and Homeostasis.International journal of molecular sciences · 2018
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erwin ReilingNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Ewoud N SpeksnijderLeiden University Medical Center, Department of Toxicogenetics, Leiden, The Netherlands.
Amanda C M PronkLeiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands.
Sjoerd A A van den Berg1] Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands [2] Amphia Hospital, Breda, The Netherlands.
Silvia J W NeggersLeiden University Medical Center, Central Animal Facility, Leiden, The Netherlands.
Ilma RietbroekLeiden University Medical Center, Central Animal Facility, Leiden, The Netherlands.
Harry van Steeg1] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands [2] Leiden University Medical Center, Department of Toxicogenetics, Leiden, The Netherlands.
Martijn E T DolléNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Leiden University Medical Center · NLNational Institute for Public Health and the Environment · NL

Funding

Models for DNA repair and cell cycle control variantsU01ES011044 · NIEHS · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 2001 to 2006
$5.1M
NIEHS NIH HHS 1UO ES11044NIEHS NIH HHS U01 ES011044
6 · The paper itself

Abstract

Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.

Indexed as

Polymorphism, Single NucleotideAgingAllelesAnimalsBody CompositionBody WeightGlucoseGlucose Tolerance TestHumansMiceMice, Inbred C57BLMice, TransgenicModels, AnimalTumor Suppressor Protein p53GlucoseTumor Suppressor Protein p53

Identifiers

PMID24522546
PMCPMC3923217
OpenAlexW2048168078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.