ArticleThe journal of nutrition, health & aging2014
Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications.
Article in The journal of nutrition, health & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- L-Arginine supplementation as mitochondrial therapy in diabetic cardiomyopathy.Cardiovascular diabetology · 2024Article
- Evaluation of a Cosmetic Formulation Containing Arginine Glutamate in Patients with Burn Scars: A Pilot Study.Pharmaceutics · 2024Article
- Nitric Oxide as a Determinant of Human Longevity and Health Span.International journal of molecular sciences · 2023Review
- Tailored biomedical materials for wound healing.Burns & trauma · 2023Review
- A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing.Bioactive materials · 2022Article
- Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets.Animal bioscience · 2022Article
- Role of arginine supplementation on muscular metabolism and flesh quality of Pacific white shrimp (Frontiers in nutrition · 2022Article
- A review of applications of metabolomics in osteoarthritis.Clinical rheumatology · 2021Review
- Article
- Metabolomics of osteoarthritis: emerging novel markers and their potential clinical utility.Rheumatology (Oxford, England) · 2018Review
- Doping in Sports, a Never-Ending Story?Advanced pharmaceutical bulletin · 2018Article
- The second case of a young man with L-arginine-induced acute pancreatitis.Clinical journal of gastroenterology · 2018Article
- The effect of dietary asparagine supplementation on energy metabolism in liver of weaning pigs when challenged with lipopolysaccharide.Asian-Australasian journal of animal sciences · 2018Article
- Effect of Polyhydroxybutyrate (PHB) storage on L-arginine production in recombinant Corynebacterium crenatum using coenzyme regulation.Microbial cell factories · 2016Article
- Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?Journal of clinical biochemistry and nutrition · 2015Article
- Brain metabolism and Alzheimer's disease: the prospect of a metabolite-based therapy.The journal of nutrition, health & aging · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the body can synthesize L-arginine, exogenous supplementation may be sometimes necessary, especially in particular conditions which results in depleted endogenous source. Among diseases and states when exogenous supplementation may be necessary are: burns, severe wounds, infections, insufficient circulation, intensive physical activity or sterility. In recent time, the attention was paid to the use of L-arginine supplementation by athletes during intensive sport activity, to enhance tissue growth and general performance, to potentiate the ergogenic potential and muscle tolerance to high intensive work and gas exchange threshold, to decrease ammonia liberation and recovery performance period and to improve wound healing. High-intensity exercise produces transient hyperammoniemia, presumably due to AMP catabolism. Catabolic pathways of AMP may involve its deamination or dephosphorylation, mainly in order to compensate fall in adenylate enrgy charge (AEC), due to AMP rise. The enzymes of purine metabolism have been documented to be particularly sensitive to the effect of dietary L-arginine supplementation. L-arginine supplementation leads to redirection of AMP deamination on account of increased AMP dephosphorylation and subsequent adenosine production and may increase ATP regeneration via activation of AMP kinase (AMPK) pathway. The central role of AMPK in regulating cellular ATP regeneration, makes this enzyme as a central control point in energy homeostasis. The effects of L-arginine supplementation on energy expenditure were successful independently of age or previous disease, in young sport active, elderly, older population and patients with angina pectoris.
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