ArticleEnvironmental science and pollution research international2014
ALAD genotypes and blood lead levels of neonates and children from e-waste exposure in Guiyu, China.
Article in Environmental science and pollution research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Health consequences of exposure to e-waste: an updated systematic review.The Lancet. Planetary health · 2021Pooled it
- Human Body Burden of Heavy Metals and Health Consequences of Pb Exposure in Guiyu, an E-Waste Recycling Town in China.International journal of environmental research and public health · 2021Review
- Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.Environmental science and pollution research international · 2021Review
- Smelting Remains a Public Health Risk Nearly a Century Later: A Case Study in Pueblo, Colorado, USA.International journal of environmental research and public health · 2018Article
- Comparison of soil heavy metal pollution caused by e-waste recycling activities and traditional industrial operations.Environmental science and pollution research international · 2017Article
- Association between blood erythrocyte lead concentrations and hemoglobin levels in preschool children.Environmental science and pollution research international · 2015Article
- E-waste environmental contamination and harm to public health in China.Frontiers of medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive e-waste recycling activity in Guiyu, China, has been conducted using primitive techniques for the last 20 years, resulting in serious heavy metal environmental contamination. A polymorphic variant of the δ-aminolevulinic acid dehydratase (ALAD) gene has been found to influence lead uptake and, thus, may influence an individual's susceptibility to lead toxicity. We therefore explored whether the ALAD gene polymorphism affects blood lead levels of newborns and children in Guiyu. A total of 273 newborns and 504 children, and a combination of 2004/2005 and 2006 independent recruitments were used for this study. Umbilical cord blood from newborns (Guiyu/exposed group 189 vs. Chaonan/reference group 84) and venous blood from children (exposed group, 319 vs. Chendian/reference group 185) were collected. Blood lead levels (BLLs) were measured via graphite furnace atomic absorption spectrometry (GFAAS) for all samples, while ALAD genotyping was performed using PCR-RFLP for 273 neonate cord blood and 246 children's blood. The median BBLs of neonates in exposed group vs. the reference group were 10.50 (2.36-40.78) vs. 7.79 (0.8-19.51) for 2004/2005 and 9.41 (9.28-47.60) vs. 5.49 (0.35-18.68) for 2006, while child mean BLLs were 15.31 ± 5.79 vs. 9.94 ± 4.05 for 2004/2005 and 13.17 ± 5.98 vs. 10.04 ± 4.85 for 2006. The genotype frequencies in newborns were 98.90 % for the ALAD-1/ALAD-1 homozygote and 1.10% for the ALAD-1/ALAD-2 heterozygotes, while the values were 95.93 and 4.07%, respectively, in children. The allele frequencies of the ALAD-1 and ALAD-2 were 99.45 and 0.55% for newborns, but 97.97 and 2.03% for children, respectively. No significant differences in blood lead levels were found between ALAD-1/ALAD-1 and ALAD-1/ALAD-2 either in newborns or in children. The frequency distribution of the ALAD-2 allele in newborns from the exposed group was lower than that of the reference group. There were no significant differences, between the two different ALAD genotypes in the lead load of newborns and children. The frequency distribution of ALAD gene does not influence the blood lead levels of newborns and children in this case, which means that the higher lead burden in the exposed children was possibly influenced by e-waste recycling, but not ALAD genotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.