Evidence map›Paper›PMID 24522100›Full record

Observational studyPediatric research2014

Effect of temperature on thromboelastography and implications for clinical use in newborns undergoing therapeutic hypothermia.

Katie R Forman, Edward Wong, Meanavy Gallagher, Robert McCarter, Naomi L C Luban, An N Massaro

Registry-linked trialOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03214120 (Does Modified Ultrafiltration Affect Thromboelastography Results?), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03214120 completednot on this mapstarted 2018, after this paper: background citation

Does Modified Ultrafiltration Affect Thromboelastography Results?

Typeobservational_patient_registrySponsorWake Forest University Health SciencesRan2018 to 2019Enrolled40ConditionsCongenital Heart Disease
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. The effect of analytical temperature on thromboelastography tracings in dogs.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
  13. Article
  14. Therapeutic hypothermia in acute liver failure: a multicenter retrospective cohort analysis.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2015
    Article
  15. Article
  16. Review of Thromboelastography (TEG): Medical and Surgical Applications.Therapeutic advances in pulmonary and critical care medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Katie R Forman1] Division of Neonatology, Children's National Medical Center, Washington, DC [2] Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC.
Edward Wong1] Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC [2] Division of Laboratory Medicine, Children's National Medical Center, Washington, DC [3] Department of Pathology, The George Washington University School of Medicine and Health Sciences, Washington, DC.
Meanavy GallagherDivision of Laboratory Medicine, Children's National Medical Center, Washington, DC.
Robert McCarter1] Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC [2] Division of Biostatistics and Informatics, Children's National Medical Center, Washington, DC [3] Department of Epidemiology and Biostatistics, The George Washington University School of Medicine and Health Sciences, Washington, DC.
Naomi L C Luban1] Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC [2] Division of Laboratory Medicine, Children's National Medical Center, Washington, DC [3] Department of Pathology, The George Washington University School of Medicine and Health Sciences, Washington, DC.
An N Massaro1] Division of Neonatology, Children's National Medical Center, Washington, DC [2] Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC.
George Washington University · USChildren's National · US

Funding

NEUROIMAGING COREP30HD040677 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2001 to 2015
$15.9M
Clinical and Translational Science Institute at Children's NationalKL2RR031987 · NCRR · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2010 to 2011
$425k
NCRR NIH HHS KL2 RR031987NICHD NIH HHS P30 HD040677
6 · The paper itself

Abstract

backgroundEncephalopathic neonates undergoing therapeutic hypothermia have increased risk for coagulopathy secondary to perinatal asphyxia and effects of cooling on the coagulation enzyme cascade. Thromboelastography (TEG) allows for a comprehensive assessment of coagulation that can be regulated for temperature. TEG has not been previously evaluated in newborns undergoing hypothermia treatment.

methodsEncephalopathic neonates treated with systemic hypothermia were enrolled in this prospective observational study. Daily blood specimens were collected for standard coagulation tests and platelet counts during hypothermia and after rewarming. Concurrent TEG assays were performed at 33.5 and 37.0 °C for comparison.

resultsA total of 48 paired TEGs from 24 subjects were performed. Forty percent of the subjects were males, the mean (± SD) birth weight was 3.2 ± 0.7 kg, and the mean gestational age was 38.4 ± 1.4 wk. TEG results differed significantly between assays performed at 37.0 vs. 33.5 °C, indicating more impaired coagulation at 33.5 °C. TEG parameters clot kinetics, angle, maximum amplitude (MA), and coagulation index were significantly associated with clinical bleeding (P < 0.05). These remained significant (except for MA) after controlling for transfusion therapy.

conclusionTEG results are affected by temperature, consistent with the known association of hypothermia with coagulopathy. Several TEG parameters are predictive of clinical bleeding in newborns undergoing hypothermia. Selected cutpoints to predict bleeding risk are temperature dependent.

Indexed as

Blood CoagulationBrain IschemiaFemaleHumansHyperammonemiaHypothermia, InducedInfant, NewbornMaleProspective StudiesRiskTemperatureThrombelastography

Identifiers

PMID24522100
PMCPMC3992188
OpenAlexW1964034792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.