ArticleThe Journal of allergy and clinical immunology2014
Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006.
Article in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 3 of them syntheses that pooled it.
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169 citing papers in PubMed, 3 syntheses or guidelines pooled it.
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- Plasma protein signatures of adult asthma.Allergy · 2024Pooled it
- REGN1908-1909 monoclonal antibodies block Fel d 1 in cat allergic subjects: Translational pharmacokinetics and pharmacodynamics.Clinical and translational science · 2021Trial
- CDC42-related genes are upregulated in helper T cells from obese asthmatic children.The Journal of allergy and clinical immunology · 2018Trial
- Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents.The Journal of allergy and clinical immunology · 2016Trial
- Reported Symptoms Upon Exposure to Aeroallergen Highly Predict Allergen Sensitization Among 12-Year-Old Children.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- A Case for Anti-IgE Vaccination.Allergy · 2026Review
- Temporal Patterns of Allergen Sensitisation in the General Population: The LEAD Study.Clinical and translational allergy · 2026Article
- Tree pollen allergen sensitization: Prevalence, risk factors, and geographic variation in the United States.The journal of allergy and clinical immunology. Global · 2026Article
- Analysis of the results of specific IgE detection for cat and dog dander allergens in 141, 165 tests with allergic diseases.BMC immunology · 2026Article
- Allergen Sensitization in Atopic Dermatitis: Distinction from Controls and Prediction of Respiratory Allergies.International archives of allergy and immunology · 2026Article
- Allergy to Cats: Current Perspectives and Therapeutic Options.Clinical and translational allergy · 2026Review
- Electron microscopy and molecular phylogenetic characterization of the allergenic dust mite species Suidasia pontifica (Acari: Suidasiidae).Experimental & applied acarology · 2026Article
- Taming pet allergens: strategies to make furry cats less allergenic.Frontiers in allergy · 2026Review
- Prevalence and Patterns of Allergen Sensitization in Southern China: A Retrospective Analysis of 18,777 Routine Checkup Participants in Shenzhen.Journal of asthma and allergy · 2026Article
- Inhalant Allergen Sensitization: Prevalence, Risk Factors, and Geographic Variation in the USA.International archives of allergy and immunology · 2026Article
- Leveraging machine learning models to forecast pediatric allergic rhinitis exacerbation risk based on environmental exposure data.Frontiers in pediatrics · 2026Article
- Relative contributions of environmental pollen exposure and host susceptibility toFrontiers in immunology · 2026Article
- Association of allergen stability and epithelial barrier function in sensitized patients.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
109 more citing papers are in PubMed but not listed here.
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Funding
Abstract
backgroundAllergic sensitization is an important risk factor for the development of atopic disease. The National Health and Nutrition Examination Survey (NHANES) 2005-2006 provides the most comprehensive information on IgE-mediated sensitization in the general US population.
objectiveWe investigated clustering, sociodemographic, and regional patterns of allergic sensitization and examined risk factors associated with IgE-mediated sensitization.
methodsData for this cross-sectional analysis were obtained from NHANES 2005-2006. Participants aged 1 year or older (n = 9440) were tested for serum specific IgEs (sIgEs) to inhalant and food allergens; participants 6 years or older were tested for 19 sIgEs, and children aged 1 to 5 years were tested for 9 sIgEs. Serum samples were analyzed by using the ImmunoCAP System. Information on demographics and participants' characteristics was collected by means of questionnaire.
resultsOf the study population aged 6 years and older, 44.6% had detectable sIgEs, whereas 36.2% of children aged 1 to 5 years were sensitized to 1 or more allergens. Allergen-specific IgEs clustered into 7 groups that might have largely reflected biological cross-reactivity. Although sensitization to individual allergens and allergen types showed regional variation, the overall prevalence of sensitization did not differ across census regions, except in early childhood. In multivariate modeling young age, male sex, non-Hispanic black race/ethnicity, geographic location (census region), and reported pet avoidance measures were most consistently associated with IgE-mediated sensitization.
conclusionsThe overall prevalence of allergic sensitization does not vary across US census regions, except in early life, although allergen-specific sensitization differs based on sociodemographic and regional factors. Biological cross-reactivity might be an important but not the sole contributor to the clustering of allergen-specific IgEs.
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