ArticleInternational journal of molecular sciences2014
Evaluation of osseointegration of titanium alloyed implants modified by plasma polymerization.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- The Cell Adhesion and Proliferation Enhancement Impact of Low-Temperature Atmospheric Pressure Plasma-Polymerized Heptylamine on the Surface of Ti6Al4V Alloy.Materials (Basel, Switzerland) · 2023Article
- Response of Osteoblasts on Amine-Based Nanocoatings Correlates with the Amino Group Density.Molecules (Basel, Switzerland) · 2023Article
- Plasma Polymerized Allylamine-The Unique Cell-Attractive Nanolayer for Dental Implant Materials.Polymers · 2019Article
- Restricted cell functions on micropillars are alleviated by surface-nanocoating with amino groups.Journal of cell science · 2018Article
- Bio-Functional Design, Application and Trends in Metallic Biomaterials.International journal of molecular sciences · 2017Review
- Quantification of osseointegration of plasma-polymer coated titanium alloyed implants by means of microcomputed tomography versus histomorphometry.BioMed research international · 2015Article
- Advances in the surface modification techniques of bone-related implants for last 10 years.Regenerative biomaterials · 2014Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By means of plasma polymerization, positively charged, nanometre-thin coatings can be applied to implant surfaces. The aim of the present study was to quantify the adhesion of human bone cells in vitro and to evaluate the bone ongrowth in vivo, on titanium surfaces modified by plasma polymer coatings. Different implant surface configurations were examined: titanium alloy (Ti6Al4V) coated with plasma-polymerized allylamine (PPAAm) and plasma-polymerized ethylenediamine (PPEDA) versus uncoated. Shear stress on human osteoblast-like MG-63 cells was investigated in vitro using a spinning disc device. Furthermore, bone-to-implant contact (BIC) was evaluated in vivo. Custom-made conical titanium implants were inserted at the medial tibia of female Sprague-Dawley rats. After a follow-up of six weeks, the BIC was determined by means of histomorphometry. The quantification of cell adhesion showed a significantly higher shear stress for MG-63 cells on PPAAm and PPEDA compared to uncoated Ti6Al4V. Uncoated titanium alloyed implants showed the lowest BIC (40.4%). Implants with PPAAm coating revealed a clear but not significant increase of the BIC (58.5%) and implants with PPEDA a significantly increased BIC (63.7%). In conclusion, plasma polymer coatings demonstrate enhanced cell adhesion and bone ongrowth compared to uncoated titanium surfaces.
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