ArticlePlant physiology2014
Elements required for an efficient NADP-malic enzyme type C4 photosynthesis.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 81 citations in OpenAlex.
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- Adaptive Responses of Tropical Crops: A Multi-Scale Omics Integrated Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Metabolite profiling reveals slow and uncoordinated adjustment of C4 photosynthesis to sudden changes in irradiance.Plant physiology · 2025Article
- Designing a nitrogen-efficient cold-tolerant maize for modern agricultural systems.The Plant cell · 2025Review
- Testing the kinetic tradeoff between bicarbonate versus phosphoenolpyruvate affinity and glucose-6 phosphate response of phosphoenolpyruvate carboxylase from two CPhotosynthesis research · 2025Article
- Perspectives on improving photosynthesis to increase crop yield.The Plant cell · 2024Review
- From leaf to multiscale models of photosynthesis: applications and challenges for crop improvement.Photosynthesis research · 2024Review
- Overexpression of chloroplastic Zea mays NADP-malic enzyme (ZmNADP-ME) confers tolerance to salt stress in Arabidopsis thaliana.Photosynthesis research · 2023Article
- Lessons from relatives: C4 photosynthesis enhances CO2 assimilation during the low-light phase of fluctuations.Plant physiology · 2023Article
- Two major metabolic factors for an efficient NADP-malic enzyme type C4 photosynthesis.Plant physiology · 2022Article
- Activation of COFrontiers in plant science · 2022Article
- Elucidation of Triacylglycerol Overproduction in the CFrontiers in plant science · 2022Article
- The limiting factors and regulatory processes that control the environmental responses of COecologia · 2021Review
- Potential metabolic mechanisms for inhibited chloroplast nitrogen assimilation under high CO2.Plant physiology · 2021Article
- Role of bundle sheath conductance in sustaining photosynthesis competence in sugarcane plants under nitrogen deficiency.Photosynthesis research · 2021Article
- Modeling photosynthetic resource allocation connects physiology with evolutionary environments.Scientific reports · 2021Article
- The coordination of major events in CScientific reports · 2021Article
- Towards a dynamic photosynthesis model to guide yield improvement in C4 crops.The Plant journal : for cell and molecular biology · 2021Article
- Efficient Regulation of COFrontiers in plant science · 2021Article
- Global Identification and Systematic Analysis of Lysine Malonylation in Maize (Frontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C4 photosynthesis has higher light, nitrogen, and water use efficiencies than C3 photosynthesis. Although the basic anatomical, cellular, and biochemical features of C4 photosynthesis are well understood, the quantitative significance of each element of C4 photosynthesis to the high photosynthetic efficiency are not well defined. Here, we addressed this question by developing and using a systems model of C4 photosynthesis, which includes not only the Calvin-Benson cycle, starch synthesis, sucrose synthesis, C4 shuttle, and CO₂ leakage, but also photorespiration and metabolite transport between the bundle sheath cells and mesophyll cells. The model effectively simulated the CO₂ uptake rates, and the changes of metabolite concentrations under varied CO₂ and light levels. Analyses show that triose phosphate transport and CO₂ leakage can help maintain a high photosynthetic rate by balancing ATP and NADPH amounts in bundle sheath cells and mesophyll cells. Finally, we used the model to define the optimal enzyme properties and a blueprint for C4 engineering. As such, this model provides a theoretical framework for guiding C4 engineering and studying C4 photosynthesis in general.
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