ArticleExperimental animals2014
Pregnancy loss following coxsackievirus b3 infection in mice during early gestation due to high expression of coxsackievirus-adenovirus receptor (CAR) in uterus and embryo.
Article in Experimental animals, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- The application and discovery of animal models in enterovirus research.Archives of virology · 2025Review
- Coxsackievirus Group B Infections during Pregnancy: An Updated Literature Review.Journal of clinical medicine · 2024Review
- Uterine Injury Caused by Genotype 4 Hepatitis E Virus Infection Based on a BALB/c Mice Model.Viruses · 2021Article
- Coxsackievirus B3 Infection of Human iPSC Lines and Derived Primary Germ-Layer Cells Regarding Receptor Expression.International journal of molecular sciences · 2021Article
- Coxsackievirus B3 Infection Early in Pregnancy Induces Congenital Heart Defects Through Suppression of Fetal Cardiomyocyte Proliferation.Journal of the American Heart Association · 2021Article
- Recent Updates on Research Models and Tools to Study Virus-Host Interactions at the Placenta.Viruses · 2019Review
- Pancreas of coxsackievirus-infected dams and their challenged pups: A complex issue.Virulence · 2019Article
- Adverse effects of maternal enterovirus infection on the pregnancy outcome: a prospective and retrospective pilot study.Virology journal · 2018Article
- Coxsackievirus B3 infection reduces female mouse fertility.Experimental animals · 2015Article
- Coxsackievirus B infection is highly related with missed abortion in Korea.Yonsei medical journal · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coxsackieviruses are important pathogens in children and the outcomes of neonatal infection can be serious or fatal. However, the outcomes of coxsackievirus infection during early gestation are not well defined. In this study, we examined the possibility of vertical transmission of coxsackievirus B3 (CVB3) and the effects of CVB3 infection on early pregnancy of ICR mice. We found that the coxsackievirus and adenovirus receptor (CAR) was highly expressed not only in embryos but also in the uterus of ICR mice. CVB3 replicated in the uterus 1 to 7 days post-infection (dpi), with the highest titer at 3 dpi. The pregnancy loss rate in mice infected with CVB3 during early gestation was 38.3%, compared to 4.7% and 2.7% in mock-infected and UV-inactivated-CVB3 infected pregnant mice, respectively. These data suggest that the uterus and embryo, which express abundant CAR, are important targets of CVB3 and that the vertical transmission of CVB3 during early gestation induces pregnancy loss.
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