ArticleCritical care (London, England)2014
Fever in sepsis: is it cool to be hot?
Article in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Lactylated Histone H3K18 as a Potential Biomarker for the Diagnosis and Predicting the Severity of Septic Shock.Frontiers in immunology · 2021Trial
- Engineering a multifunctional nanoplatform with cascade catalytic and bidirectional immunomodulatory capacities for integrating sepsis therapy.Journal of advanced research · 2026Article
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- Machine learning prediction of early hypothermia in sepsis patients.Archives of medical science : AMS · 2026Article
- Temperature profiles in adult intensive care unit patients treated for infection in a tertiary intensive care unit: A single-centre prospective observational cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.Journal of intensive care · 2025Article
- Article
- Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis.Journal of nanobiotechnology · 2023Article
- Clinical Sepsis Phenotypes in Critically Ill Patients.Microorganisms · 2023Review
- Bioengineered stem cell membrane functionalized nanoparticles combine anti-inflammatory and antimicrobial properties for sepsis treatment.Journal of nanobiotechnology · 2023Article
- Neutrophil extracellular traps formation and clearance is enhanced in fever and attenuated in hypothermia.Frontiers in immunology · 2023Article
- Activation of CBJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Predicting Adverse Outcomes for Febrile Patients in the Emergency Department Using Sparse Laboratory Data: Development of a Time Adaptive Model.JMIR medical informatics · 2020Article
- Predictors of 30-Day In-Hospital Mortality in Patients Undergoing Urgent Abdominal Surgery Due to Acute Peritonitis Complicated with Sepsis.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Epigenetics in Sepsis: Understanding Its Role in Endothelial Dysfunction, Immunosuppression, and Potential Therapeutics.Frontiers in immunology · 2019Review
- Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria.Critical care medicine · 2016Article
- Morphology-Independent Virulence of Candida Species during Polymicrobial Intra-abdominal Infections with Staphylococcus aureus.Infection and immunity · 2016Article
- Touch-free measurement of body temperature using close-up thermography of the ocular surface.MethodsX · 2016Article
- Temperature modulation with an esophageal heat transfer device - a pediatric swine model study.BMC anesthesiology · 2015Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.Acute medicine & surgeryArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in body temperature are a characteristic feature of sepsis. The study by Kushimoto and colleagues in a recent issue of Critical Care demonstrates that hypothermia is a very important manifestation of infection associated with very high mortality. Combined with recent data suggesting that febrile patients with infections have the lowest mortality risk, the study raises the question of whether inducing therapeutic hyperthermia might be beneficial in this patient group. Body temperature is easily measured and manipulated in the ICU, and interventional trials defining the most appropriate temperature targets in ICU patients with infections are urgently needed. One such study is in progress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.