Trial reportPreventive medicine2014
Can we build an efficient response to the prescription drug abuse epidemic? Assessing the cost effectiveness of universal prevention in the PROSPER trial.
Trial report in Preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Family-Based Interventions to Prevent Substance Use Among Youth: Community Guide Systematic Economic Review.American journal of preventive medicine · 2025Pooled it
- Evidence for state, community and systems-level prevention strategies to address the opioid crisis.Drug and alcohol dependence · 2019Pooled it
- Enhancing risk perception may be insufficient to curtail prescription opioid use and misuse among youth after surgery: A randomized controlled trial.Patient education and counseling · 2022Trial
- Prescription Pain Medication Misuse with and Without Heroin Use Among Adolescents: relationships with Routine Healthcare, Family Support, Academic Performance, Violence, and Other Risky Behaviors.Substance use & misuse · 2025Article
- Resource Realities: Exploring the Foundations of Successful Implementation in School-Based Drug Prevention.The Journal of school health · 2024Article
- Substance Use Disorders: Population Prevention.Focus (American Psychiatric Publishing) · 2024Article
- Integrated Prevention Infrastructure: A Framework for Addressing Social Determinants of Health in Substance Use Policy Making.Focus (American Psychiatric Publishing) · 2024Article
- The ABCD and HBCD Studies: Longitudinal Studies to Inform Prevention Science.Focus (American Psychiatric Publishing) · 2024Review
- A Video Game Intervention to Prevent Opioid Misuse Among Older Adolescents: Development and Preimplementation Study.JMIR serious games · 2023Article
- Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Economic Evaluation Design within the HEAL Prevention Cooperative.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Health Care Provider Stigma Toward Patients With Substance Use Disorders: Protocol for a Nationally Representative Survey.JMIR research protocols · 2023Article
- A systematic review of economic evaluations for opioid misuse, cannabis and illicit drug use prevention.BJPsych open · 2023Review
- Sri Lanka's response to prescribed drug misuse: is it enough?BJPsych international · 2023Review
- Polysubstance Use, Mood Disorders, and Chronic Conditions With Anxiety in Opioid Patients.Western journal of nursing research · 2022Article
- Reducing opioid use disorder and overdose deaths in the United States: A dynamic modeling analysis.Science advances · 2022Article
- A National Cost Analysis of Community Interventions to Prevent Underage Drinking and Prescription Drug Misuse.Prevention science : the official journal of the Society for Prevention Research · 2021Article
- Guidelines for Opioid Prescribing in Children and Adolescents After Surgery: An Expert Panel Opinion.JAMA surgery · 2021Review
- Understanding the increase in opioid overdoses in New Hampshire: A rapid epidemiologic assessment.Drug and alcohol dependence · 2020Article
- Prescription opioid misuse among adolescents and emerging adults in the United States: A scoping review.Preventive medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposePrescription drug abuse has reached epidemic proportions. Nonmedical prescription opioid use carries increasingly high costs. Despite the need to cultivate efforts that are both effective and fiscally responsible, the cost-effectiveness of universal evidence-based-preventive-interventions (EBPIs) is rarely evaluated. This study explores the performance of these programs to reduce nonmedical prescription opioid use.
methodsSixth graders from twenty-eight rural public school districts in Iowa and Pennsylvania were blocked by size and geographic location and then randomly assigned to experimental or control conditions (2002-2010). Within the intervention communities, prevention teams selected a universal family and school program from a menu of EBPIs. All families were offered a family-based program in the 6th grade and received one of three school-based programs in 7th-grade. The effectiveness and cost-effectiveness of each school program by itself and with an additional family-based program were assessed using propensity and marginal structural models.
resultsThis work demonstrates that universal school-based EBPIs can efficiently reduce nonmedical prescription opioid use. Further, findings illustrate that family-based programs may be used to enhance the cost-effectiveness of school-based programs.
conclusionsUniversal EBPIs can effectively and efficiently reduce nonmedical prescription opioid use. These programs should be further considered when developing comprehensive responses to this growing national crisis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.