Evidence map›Paper›PMID 2452126›Full record

ArticleHuman genetics1988

Relationships between DNA and protein polymorphisms of apolipoprotein B.

A M Dunning, M J Tikkanen, C Ehnholm, R Bütler, S E Humphries

Abstract read
PubMed Publisher
In one paragraph

Article in Human genetics, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

A M DunningCharing Cross Sunley Research Centre, Hammersmith, London, UK.
M J Tikkanen
C Ehnholm
R Bütler
S E Humphries
Charing Cross Hospital · GBInstitute for Molecular Medicine Finland · FISwiss Red Cross · CHUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The associations between four restriction fragment length polymorphisms (RFLPs) of the gene for human apolipoprotein B (apo B) and five antigen group (Ag) protein-polymorphisms of apo B have been investigated in 24 unrelated Finnish individuals. In this sample a complete correlation exists between the EcoRI RFLP and the Ag(t/z) polymorphism. There is strong association between the alleles of the XbaI RFLP and Ag(c/g) and a weaker one of the same XbaI site with Ag(x/y). Linkage disequilibrium is observed between the PvuII RFLP and the Ag(a1/d) polymorphism. These associations confirm that the Ag variants are true protein sequence polymorphisms of apo B.

Indexed as

Polymorphism, GeneticPolymorphism, Restriction Fragment LengthApolipoproteins BDeoxyribonuclease EcoRIDNADNA Restriction EnzymesEpitopesGenetic LinkageGenetic MarkersHumansPhenotypeApolipoproteins BDeoxyribonuclease EcoRIDNADNA Restriction EnzymesEpitopesGenetic Markers

Identifiers

PMID2452126
OpenAlexW2004681599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.