ArticleDiabetes, obesity & metabolism2014
Artemisia dracunculus L. extract ameliorates insulin sensitivity by attenuating inflammatory signalling in human skeletal muscle culture.
Article in Diabetes, obesity & metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- Research progress on the effects of adverse exposure during pregnancy on skeletal muscle function in the offspring.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Extract ofInternational journal of molecular sciences · 2023Article
- Spicy and Aromatic Plants for Meat and Meat Analogues Applications.Plants (Basel, Switzerland) · 2022Review
- Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- The DESIGNER Approach Helps Decipher the Hypoglycemic Bioactive Principles ofJournal of natural products · 2019Article
- The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans.Metabolism: clinical and experimental · 2019Article
- Potential adverse effects of botanical supplementation in high-fat-fed female mice.Biology of sex differences · 2018Article
- An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation.Molecular nutrition & food research · 2018Article
- An Extract ofOxidative medicine and cellular longevity · 2018Article
- An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes.Frontiers in pharmacology · 2017Review
- Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice.Scientific reports · 2016Article
- Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle.Cell reports · 2016Article
- Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes.PloS one · 2016Article
- Identification of Eupatilin from Artemisia argyi as a Selective PPARα Agonist Using Affinity Selection Ultrafiltration LC-MS.Molecules (Basel, Switzerland) · 2015Article
- Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents.Journal of agricultural and food chemistry · 2015Article
- Aqueous and alcoholic extracts ofAvicenna journal of phytomedicineArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aimsBioactives of Artemisia dracunculus L. (termed PMI 5011) have been shown to improve insulin action by increasing insulin signalling in skeletal muscle. However, it was not known if PMI 5011's effects are retained during an inflammatory condition. We examined the attenuation of insulin action and whether PMI 5011 enhances insulin signalling in the inflammatory environment with elevated cytokines.
methodsMuscle cell cultures derived from lean, overweight and diabetic-obese subjects were used. Expression of pro-inflammatory genes and inflammatory response of human myotubes were evaluated by real-time polymerase chain reaction (RT-PCR). Insulin signalling and activation of inflammatory pathways in human myotubes were evaluated by multiplex protein assays.
resultsWe found increased gene expression of monocyte chemoattractant protein 1 (MCP1) and TNFα (tumour necrosis factor alpha), and basal activity of the NFkB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathway in myotubes derived from diabetic-obese subjects as compared with myotubes derived from normal-lean subjects. In line with this, basal Akt phosphorylation (Ser473) was significantly higher, while insulin-stimulated phosphorylation of Akt (Ser473) was lower in myotubes from normal-overweight and diabetic-obese subjects compared with normal-lean subjects. PMI 5011 treatment reduced basal phosphorylation of Akt and enhanced insulin-stimulated phosphorylation of Akt in the presence of cytokines in human myotubes. PMI 5011 treatment led to an inhibition of cytokine-induced activation of inflammatory signalling pathways such as Erk1/2 and IkBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)-NFkB and moreover, NFkB target gene expression, possibly by preventing further propagation of the inflammatory response within muscle tissue.
conclusionsPMI 5011 improved insulin sensitivity in diabetic-obese myotubes to the level of normal-lean myotubes despite the presence of pro-inflammatory cytokines.
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