ArticleAddiction (Abingdon, England)2014
Maternal smoking during pregnancy and offspring smoking initiation: assessing the role of intrauterine exposure.
Article in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review.European journal of epidemiology · 2024Pooled it
- The association of maternal sugary beverage consumption during pregnancy and the early years with childhood sugary beverage consumption.Canadian journal of public health = Revue canadienne de sante publique · 2023Pooled it
- A Systematic Review of Mental Health Professionals, Patients, and Carers' Perceived Barriers and Enablers to Supporting Smoking Cessation in Mental Health Settings.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Pooled it
- Mendelian randomisation approaches to the study of prenatal exposures: A systematic review.Paediatric and perinatal epidemiology · 2021Pooled it
- Prenatal smoking exposure and cardio-metabolic risk factors in adulthood: a general population study and a meta-analysis.International journal of obesity (2005) · 2019Pooled it
- Comparison of nicotine exposure during pregnancy when smoking and abstinent with nicotine replacement therapy: systematic review and meta-analysis.Addiction (Abingdon, England) · 2019Pooled it
- A systematic review and narrative summary of family-based smoking cessation interventions to help adults quit smoking.BMC family practice · 2016Pooled it
- Associations of parental smoking throughout childhood with adolescent smoking and vaping: Mediation via adolescent substance use attitudes.Drug and alcohol dependence · 2026Article
- Antenatal Maternal Smoking and Lung Function in Very Prematurely Born Children.Pediatric pulmonology · 2026Article
- Association between maternal smoking during pregnancy and smoking behaviors in adult offspring.Frontiers in public health · 2025Article
- Assessing Causality Between Second-Hand Smoking and Potentially Associated Diseases in Multiple Systems: A Two-Sample Mendelian Randomization Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Family functioning and nicotine dependence among smoking fathers: a cross-sectional study.BMC public health · 2023Article
- Promoting and Maintaining Changes in Smoking Behavior for Patients Following Discharge from a Smoke-free Mental Health Inpatient Stay: Development of a Complex Intervention Using the Behavior Change Wheel.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Maternal smoking around birth may lower the protective effects of breastfeeding on anxiety, depression and neuroticism in adult offspring: a UK biobank study.European archives of psychiatry and clinical neuroscience · 2023Article
- Are E-cigarettes associated with postpartum return to smoking? Secondary analyses of a UK pregnancy longitudinal cohort.BMJ open · 2022Article
- Estimating causal and time-varying effects of maternal smoking on youth smoking.Addictive behaviors · 2021Article
- Maternal prenatal thyroid function and trajectories of offspring emotional and behavioural problems: findings from the ALSPAC cohort.European child & adolescent psychiatry · 2020Article
- DNA methylation links prenatal smoking exposure to later life health outcomes in offspring.Clinical epigenetics · 2019Article
- Toward an Intergenerational Model for Tobacco-Focused CBPR: Integrating Youth Perspectives via Photovoice.Health promotion practice · 2019Article
- Maternal smoking during pregnancy and autism: using causal inference methods in a birth cohort study.Translational psychiatry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
aimsTo assess whether associations between maternal smoking during pregnancy and offspring smoking initiation are due to intrauterine mechanisms.
designComparison of associations of maternal and partner smoking behaviour during pregnancy with offspring smoking initiation using partner smoking as a negative control (n = 6484) and a Mendelian randomization analysis (n = 1020), using a genetic variant in the mothers as a proxy for smoking cessation during pregnancy.
settingA longitudinal birth cohort in South West England.
participantsParticipants of the Avon Longitudinal Study of Parents and Children (ALSPAC). MEASUREMENTS: Smoking status during pregnancy was self-reported by mother and partner in questionnaires administered at pregnancy. Latent classes of offspring smoking initiation (non-smokers, experimenters, late-onset regular smokers and early-onset regular smokers) were previously developed from questionnaires administered at 14-16 years. A genetic variant, rs1051730, was genotyped in the mothers.
findingsBoth mother and partner smoking were similarly positively associated with offspring smoking initiation classes, even after adjustment for confounders. Odds ratios (OR) [95% confidence interval (CI)] for class membership compared with non-smokers were: experimenters: mother OR = 1.33 (95% CI = 1.06, 1.67), partner OR = 1.28 (95% CI = 1.06, 1.55), late-onset regular smokers: mother OR = 1.80 (95% CI = 1.43, 2.26), partner OR = 1.86 (95% CI = 1.52, 2.28) and early-onset regular smokers: mother OR = 2.89 (95% CI = 2.12, 3.94), partner OR = 2.50 (95% CI = 1.85, 3.37). There was no clear evidence for a dose-response effect of either mother or partner smoking heaviness on class membership. Maternal rs1051730 genotype was not clearly associated with offspring smoking initiation class in pre-pregnancy smokers (P = 0.35).
conclusionThe association between smoking during pregnancy and offspring smoking initiation does not appear to operate through intrauterine mechanisms.
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