Trial reportThe American journal of drug and alcohol abuse2014
Craving predicts opioid use in opioid-dependent patients initiating buprenorphine treatment: a longitudinal study.
Trial report in The American journal of drug and alcohol abuse, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Investigating craving as an indicator of early response to buprenorphine treatment among adults with opioid use disorder.Journal of consulting and clinical psychology · 2026Trial
- Mindfulness Training vs Recovery Support for Opioid Use, Craving, and Anxiety During Buprenorphine Treatment: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Extended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal.JAMA network open · 2024Trial
- A pilot randomized clinical trial of mindfulness-oriented recovery enhancement as an adjunct to methadone treatment for people with opioid use disorder and chronic pain: Impact on illicit drug use, health, and well-being.Journal of substance abuse treatment · 2021Trial
- Laboratory-induced stress and craving predict opioid use during follow-up among individuals with prescription opioid use disorder.Drug and alcohol dependence · 2021Trial
- A preliminary randomized controlled trial of a distress tolerance treatment for opioid dependent persons initiating buprenorphine.Drug and alcohol dependence · 2015Trial
- The PPARγ Agonist Pioglitazone Fails to Alter the Abuse Potential of Heroin, But Does Reduce Heroin Craving and Anxiety.Journal of psychoactive drugsTrial
- Parabrachial CGRP Neurons Regulate Opioid Reinforcement.bioRxiv : the preprint server for biology · 2026Article
- Article
- Exploring the Utility of a Functional Magnetic Resonance Imaging Cannabis Cue-Reactivity Paradigm in Treatment-Seeking Adults With Cannabis Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Towards comprehending internet gaming disorder: evaluating the psychometric properties of the Polish adaptation of the Craving for Internet Gaming Scale.Postepy psychiatrii neurologii · 2024Article
- Development and Evaluation of a Digital App for Patient Self-Management of Opioid Use Disorder: Usability, Acceptability, and Utility Study.JMIR formative research · 2024Article
- Negative Urgency Linked to Craving and Substance Use Among Adults on Buprenorphine or Methadone.The journal of behavioral health services & research · 2024Article
- Time-varying effect modeling with intensive longitudinal data: Examining dynamic links among craving, affect, self-efficacy and substance use during addiction recovery.Addiction (Abingdon, England) · 2023Article
- Association between body mass index and treatment completion in extended-release naltrexone-treated patients with opioid dependence.Frontiers in psychiatry · 2023Article
- Intermittent access to oxycodone decreases dopamine uptake in the nucleus accumbens core during abstinence.Addiction biology · 2022Article
- Learning from addiction: Craving of prescription opioids in chronic pain sufferers.Neuroscience and biobehavioral reviews · 2022Review
- Trajectories of craving during medication-assisted treatment for opioid-use disorder: Subtyping for early identification of higher risk.Drug and alcohol dependence · 2022Article
- A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFew studies have assessed associations between craving and subsequent opioid use. We prospectively evaluated the relative utility of two craving questionnaires to predict opioid use among opioid-dependent patients in outpatient treatment.
methodOpioid-dependent patients (n = 147) initiating buprenorphine treatment were assessed every two weeks for 3 months. Craving was measured using the: (1) Desires for Drug Questionnaire (DDQ) and (2) Penn Alcohol-Craving Scale adapted for opioid craving (PCS). Multi-level logistic regression models estimated the effects of craving on the likelihood of opioid use. Craving assessed at time t was entered as a time-varying predictor of opioid use at time t + 1.
resultsCraving scores plateaued at approximately 2 weeks after initiation of buprenorphine. In adjusted regression models, a 1-point increase in PCS scores (on a 7-point scale) was associated with a significant increase in the odds of opioid use at the subsequent assessment (OR = 1.27, 95% CI 1.08; 1.49, p < 0.01). The odds of opioid use at the subsequent follow-up assessment increased significantly as DDQ desire and intention scores increased (OR = 1.25, 95%CI 1.03; 1.51, p < 0.05), but was not significantly associated with DDQ negative reinforcement (OR = 1.01, 95%CI 0.88; 1.17, p > 0.05) or DDQ control (OR = 0.97, 95%CI 0.85; 1.11, p > 0.05) scores.
conclusionSelf-reported craving for opioids was modestly associated with subsequent relapse to opioid use among a cohort of patients treated with buprenorphine. Assessment of craving may provide clinical utility in predicting relapse among treated opioid-dependent patients.
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