ArticleBMC infectious diseases2014
Asymptomatic ratio for seasonal H1N1 influenza infection among schoolchildren in Taiwan.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Can we distinguish respiratory viral infections based on clinical features? A prospective pediatric cohort compared to systematic literature review.Reviews in medical virology · 2018Pooled it
- Roles for Pathogen Interference in Influenza Vaccination, with Implications to Vaccine Effectiveness (VE) and Attribution of Influenza Deaths.Infectious disease reports · 2022Review
- Development of an RNA Strand-Specific Hybridization Assay To Differentiate Replicating versus Nonreplicating Influenza A Viruses.Journal of clinical microbiology · 2020Article
- The burden of laboratory-confirmed influenza infection in Lebanon between 2008 and 2016: a single tertiary care center experience.BMC infectious diseases · 2020Article
- Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19).International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- The potential effects of widespread community transmission of SARS-CoV-2 infection in the World Health Organization African Region: a predictive model.BMJ global health · 2020Article
- The SARS-CoV-2 pandemic course in Saudi Arabia: A dynamic epidemiological model.Infectious Disease Modelling · 2020Article
- Disease persistence on temporal contact networks accounting for heterogeneous infectious periods.Royal Society open science · 2019Article
- Asymptomatic Shedding of Respiratory Virus among an Ambulatory Population across Seasons.mSphere · 2018Article
- Asymptomatic Summertime Shedding of Respiratory Viruses.The Journal of infectious diseases · 2018Article
- Forty five percent of the Israeli population were infected with the influenza B Victoria virus during the winter season 2015-16.Oncotarget · 2018Article
- Evaluating the effects of common control measures for influenza A (H1N1) outbreak at school in China: A modeling study.PloS one · 2017Article
- Involvement of the different lung compartments in the pathogenesis of pH1N1 influenza virus infection in ferrets.Veterinary research · 2016Article
- Healthcare seeking behavior of patients with influenza like illness: comparison of the summer and winter influenza epidemics.BMC infectious diseases · 2016Article
- Assessing the Role of Voluntary Self-Isolation in the Control of Pandemic Influenza Using a Household Epidemic Model.International journal of environmental research and public health · 2015Article
- Risk factors of pandemic influenza A/H1N1 in a prospective household cohort in the general population: results from the CoPanFlu-France cohort.Influenza and other respiratory viruses · 2015Article
- Antiviral combinations for severe influenza.The Lancet. Infectious diseases · 2014Review
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies indicate that asymptomatic infections do indeed occur frequently for both seasonal and pandemic influenza, accounting for about one-third of influenza infections. Studies carried out during the 2009 pH1N1 pandemic have found significant antibody response against seasonal H1N1 and H3N2 vaccine strains in schoolchildren receiving only pandemic H1N1 monovalent vaccine, yet reported either no symptoms or only mild symptoms.
methodsSerum samples of 255 schoolchildren, who had not received vaccination and had pre-season HI Ab serotiters <40, were collected from urban, rural areas and an isolated island in Taiwan during the 2005-2006 influenza season. Their hemagglutination inhibition antibody (HI Ab) serotiters against the 2005 A/New Caledonia/20/99 (H1N1) vaccine strain at pre-season and post-season were measured to determine the symptoms with the highest correlation with infection, as defined by 4-fold rise in HI titer. We estimate the asymptomatic ratio, or the proportion of asymptomatic infections, for schoolchildren during the 2005-6 influenza season when this vaccine strain was found to be antigenically related to the circulating H1N1 strain.
resultsFever has the highest correlation with the 2005-06 seasonal influenza A(H1N1) infection, followed by headache, cough, vomiting, and sore throat. Asymptomatic ratio for the schoolchildren is found to range between 55.6% (95% CI: 44.7-66.4)-77.9% (68.8-87.0) using different sets of predictive symptoms. Moreover, the asymptomatic ratio was 66.9% (56.6-77.2) when using US-CDC criterion of fever + (cough/sore throat), and 73.0 (63.3-82.8) when under Taiwan CDC definition of Fever + (cough or sore throat or nose) + ( headache or pain or fatigue).
conclusionsAsymptomatic ratio for children is found to be substantially higher than that of the general population in literature. In providing reasonable quantification of the asymptomatic infected children spreading pathogens to others in a seasonal epidemic or a pandemic, our estimates of symptomatic ratio of infected children has important clinical and public health implications.
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