ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2014
Neonatal oxygen exposure alters airway hyper-responsiveness but not the response to allergen challenge in adult mice.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Mitochondrial quality control mechanisms as molecular targets for impaired lung development: from fetuses to neonates.Respiratory research · 2025Review
- Establishment of a juvenile mouse asthma model induced by postnatal hyperoxia exposure combined with early OVA sensitization.Heliyon · 2024Article
- Effects of early postnatal hyperoxia exposure combined with early ovalbumin sensitization on lung inflammation and bacterial flora in a juvenile mouse model of asthma.Frontiers in microbiology · 2023Article
- Low-dose hyperoxia primes airways for fibrosis in mice after influenza A infection.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.JCI insight · 2021Article
- Early origins of lung disease: towards an interdisciplinary approach.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Pulmonary mechanics and structural lung development after neonatal hyperoxia in mice.Pediatric research · 2020Article
- Correlations between oxygen and positive pressure exposure in the neonatal intensive care unit and wheezing in preterm infants without bronchopulmonary dysplasia.Journal of neonatal-perinatal medicine · 2020Article
- Rodent models of respiratory control and respiratory system development-Clinical significance.Respiratory physiology & neurobiology · 2019Review
- Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses.The Journal of allergy and clinical immunology · 2018Article
- Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.Stem cell research & therapy · 2017Article
- Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells.American journal of respiratory cell and molecular biology · 2017Article
- Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia.Disease models & mechanisms · 2017Article
- S-Nitrosoglutathione Attenuates Airway Hyperresponsiveness in Murine Bronchopulmonary Dysplasia.Molecular pharmacology · 2016Article
- Increased airway reactivity in a neonatal mouse model of continuous positive airway pressure.Pediatric research · 2015Article
- Neonatal hyperoxia leads to persistent alterations in NK responses to influenza A virus infection.American journal of physiology. Lung cellular and molecular physiology · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundInfants born prematurely are often treated with supplemental oxygen, which can increase their risk for airway hyper-responsiveness (AHR), asthma, reduced lung function, and altered responses to respiratory viral infections later in childhood. Likewise, exposure of newborn mice to hyperoxia alters baseline pulmonary mechanics and the host response to influenza A virus infection in adult mice. Here, we use this mouse model to test the hypothesis that neonatal hyperoxia also promotes AHR and exacerbated allergen-induced symptoms in adult mice.
methodsBaseline lung mechanics and AHR measured by methacholine provocation were assessed in adult male and female mice exposed to room air or 100% oxygen (hyperoxia) between post-natal days 0-4. AHR and lung inflammation were evaluated after adult female mice were sensitized with ovalbumin (OVA) plus alum and challenged with aerosolized OVA.
resultsBaseline lung compliance increased and resistance decreased in adult female, but not male, mice exposed to neonatal hyperoxia compared with siblings exposed to room air. Neonatal hyperoxia significantly enhanced methacholine-induced AHR in female mice, but did not affect allergen-induced AHR to methacholine or lung inflammation.
conclusionIncreased incidence of AHR and asthma is reported in children born prematurely and exposed to supplemental oxygen. Our findings in adult female mice exposed to hyperoxia as neonates suggest that this AHR reported in children born prematurely may reflect non-atopic wheezing due to intrinsic structural changes in airway development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.