ArticlePloS one2014
Sublethal effects of CuO nanoparticles on Mozambique tilapia (Oreochromis mossambicus) are modulated by environmental salinity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 54 citations in OpenAlex.
- Plastics as disruptors of feeding, digestive physiology, metabolism, and growth in fish and other aquatic ectothermic vertebrates.Frontiers in endocrinology · 2026Review
- Copper Nanoparticles in Aquatic Environment: Release Routes and Oxidative Stress-Mediated Mechanisms of Toxicity to Fish in Various Life Stages and Future Risks.Current issues in molecular biology · 2025Review
- Investigating the effects of copper sulfate and copper oxide nanoparticles in Nile tilapia (Oreochromis niloticus) using multiple biomarkers: the prophylactic role of Spirulina.Environmental science and pollution research international · 2021Article
- Salinity-Based Toxicity of CuO Nanoparticles, CuO-Bulk and Cu Ion toFrontiers in microbiology · 2017Article
- EU Regulation of Nanobiocides: Challenges in Implementing the Biocidal Product Regulation (BPR).Nanomaterials (Basel, Switzerland) · 2016Article
- Dissolution and biodurability: Important parameters needed for risk assessment of nanomaterials.Particle and fibre toxicology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The increasing use of manufactured nanoparticles (NP) in different applications has triggered the need to understand their putative ecotoxicological effects in the environment. Copper oxide nanoparticles (CuO NP) are toxic, and induce oxidative stress and other pathophysiological conditions. The unique properties of NP can change depending on the characteristics of the media they are suspended in, altering the impact on their toxicity to aquatic organisms in different environments. Here, Mozambique tilapia (O. mossambicus) were exposed to flame synthesized CuO NP (0.5 and 5 mg · L(-1)) in two environmental contexts: (a) constant freshwater (FW) and (b) stepwise increase in environmental salinity (SW). Sublethal effects of CuO NP were monitored and used to dermine exposure endpoints. Fish exposed to 5 mg · L(-1) CuO in SW showed an opercular ventilation rate increase, whereas fish exposed to 5 mg · L(-1) in FW showed a milder response. Different effects of CuO NP on antioxidant enzyme activities, accumulation of transcripts for metal-responsive genes, GSH ∶ GSSG ratio, and Cu content in fish gill and liver also demonstrate that additive osmotic stress modulates CuO NP toxicity. We conclude that the toxicity of CuO NP depends on the particular environmental context and that salinity is an important factor for modulating NP toxicity in fish.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.