ArticlePloS one2014
High cell-free DNA predicts fatal outcome among Staphylococcus aureus bacteraemia patients with intensive care unit treatment.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The evolving landscape ofFrontiers in immunology · 2026Pooled it
- Role of cell-free DNA levels in the diagnosis and prognosis of sepsis and bacteremia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Retrospective analysis of 300 microbial cell-free DNA sequencing results in routine blood stream infection diagnostics.Frontiers in cellular and infection microbiology · 2025Article
- Extracted Plasma Cell-Free DNA Concentrations Are Elevated in Colic Patients with Systemic Inflammation.Veterinary sciences · 2024Article
- The predictive value of peripheral blood cell mitochondrial gene expression in identifying the prognosis in pediatric sepsis at preschool age.Frontiers in cellular and infection microbiology · 2024Article
- Article
- Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics.GeroScience · 2023Article
- Investigation of plasma cell-free DNA as a potential biomarker in horses.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Development and validation of a risk score for predicting positivity of blood cultures and mortality in patients with bacteremia and fungemia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Utility of cell-free DNA concentrations and illness severity scores to predict survival in critically ill neonatal foals.PloS one · 2021Article
- Markers of neutrophil activation and extracellular traps formation are predictive of appendicitis in mice and humans: a pilot study.Scientific reports · 2020Article
- Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis.BMC pulmonary medicine · 2020Article
- Sustained Circulating Bacterial Deoxyribonucleic Acid Is Associated With ComplicatedOpen forum infectious diseases · 2019Article
- Prognostic Power of Pathogen Cell-Free DNA inOpen forum infectious diseases · 2019Article
- Article
- Effect of sample type on plasma concentrations of cell-free DNA and nucleosomes in dogs.Veterinary record open · 2019Article
- Cell-Free DNA, High-Mobility Group Box-1, and Procalcitonin Concentrations in Dogs With Gastric Dilatation-Volvulus Syndrome.Frontiers in veterinary science · 2018Article
- Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis.Journal of intensive care · 2018Article
- Concentrations of Plasma Nucleosomes but Not Cell-Free DNA Are Prognostic in Dogs Following Trauma.Frontiers in veterinary science · 2018Article
- Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9.Nature communications · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAmong patients with bacteraemia or sepsis the plasma cell-free DNA (cf-DNA) biomarker has prognostic value and Pitt bacteraemia scores predict outcome. We evaluated the prognostic value of plasma cf-DNA in patients with Staphylococcus aureus bacteraemia (SAB) treated in the ICU or in the general ward.
methods418 adult patients with positive blood culture for S. aureus were prospectively followed for 90 days. SAB patients were grouped according to ICU treatment: 99 patients were treated in ICU within 7 days of documented SAB whereas 319 patients were managed outside ICU. Pitt bacteraemia scores were assessed at hospital arrival and cf-DNA was measured at days 3 and 5 from positive blood culture.
resultsSAB patients with high Pitt bacteraemia scores and ICU treatment presented higher cf-DNA values as compared to SAB patients with low Pitt bacteraemia scores and non-ICU treatment at both days 3 and 5. Among ICU patients cf-DNA >1.99 µg/ml at day 3 predicted death with a sensitivity of 67% and a specificity of 77% and had an AUC in receiver operating characteristic analysis of 0.71 (p<0.01). The cut-off cf-DNA >1.99 µg/ml value demonstrated a strong association to high Pitt bacteraemia scores (≥ 4 points) (p<0.000). After controlling for all prognostic markers, Pitt bacteraemia scores ≥ 4 points at hospital admission (OR 4.47, p<0.000) and day 3 cf-DNA (OR 3.56, p<0.001) were the strongest factors significantly predicting outcome in ICU patients. cf-DNA at day 5 did not predict fatal outcome.
conclusionHigh cf-DNA concentrations were observed among patients with high Pitt bacteraemia scores and ICU treatment. Pitt bacteraemia scores (≥ 4 points) and cf-DNA at day 3 from positive blood culture predicted death among SAB patients in ICU and were found to be independent prognostic markers. cf-DNA had no prognostic value among non-ICU patients.
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