Evidence map›Paper›PMID 24520301›Full record

ArticleOncology letters2014

MicroRNA-23a promotes neuroblastoma cell metastasis by targeting CDH1.

Lin Cheng, Tao Yang, Yongqin Kuang, Bin Kong, Sixun Yu, Haifeng Shu, Hutian Zhou, Jianwen Gu

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  6. Review
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  9. Article
  10. Mir-23a inhibition attenuates ischemic/reperfusion-induced myocardial apoptosis by targeting XIAP.International journal of clinical and experimental pathology · 2017
    Article
  11. Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology.International journal of molecular sciences · 2016
    Review
  12. Article
  13. Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  14. Article
  15. Article
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  18. MiR-451 increases radiosensitivity of nasopharyngeal carcinoma cells by targeting ras-related protein 14 (RAB14).Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lin ChengDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Tao YangDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Yongqin KuangDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Bin KongDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Sixun YuDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Haifeng ShuDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Hutian ZhouDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Jianwen GuDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China.
Chengdu Military General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CDH1 inactivation is important in tumor metastasis. In the present study, it was suggested that the mRNA and protein levels of CDH1 decreased in metastatic neuroblastoma (NB) tissues compared with those in primary NB tissues. The aim of the study was to explore the regulatory mechanisms of CDH1 downregulation in metastatic NB. MicroRNAs are small non-coding RNAs (~22 nt in length) that negatively regulate target mRNAs and are involved in various cancer-related processes, including metastasis. In the current study, miR-23a was shown to be upregulated in human metastatic NB tissues compared with primary NB tissues. Inhibition of miR-23a may significantly suppress NB cell migration and invasion.

Indexed as

CDH1miR-23amiRNAneuroblastoma

Identifiers

PMID24520301
PMCPMC3919791
OpenAlexW1979026812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.