ReviewThe application of clinical genetics2014
Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants.
Review in The application of clinical genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Pooled it
- Significant association between the endothelial lipase gene 584C/T polymorphism and coronary artery disease risk.Bioscience reports · 2020Pooled it
- The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- The roles of ANRIL polymorphisms in coronary artery disease: a meta-analysis.Bioscience reports · 2019Pooled it
- Effects of ADIPOQ polymorphisms on individual susceptibility to coronary artery disease: a meta-analysis.Adipocyte · 2019Pooled it
- Associations of leptin and leptin receptor genetic variants with coronary artery disease: a meta-analysis.Bioscience reports · 2019Pooled it
- Associations between ADIPOQ polymorphisms and coronary artery disease: a meta-analysis.BMC cardiovascular disorders · 2019Pooled it
- Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases.BMC cardiovascular disorders · 2018Pooled it
- Pooled it
- Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.Human molecular genetics · 2016Pooled it
- Inflammatory Cytokine Genetics and Coronary Artery Disease: Pathogenetic and Protective Analysis of IL-18 (-607 C/A, -137 G/C) and IL-8 (+781 C/T) Gene Variations.Current issues in molecular biology · 2026Article
- Article
- Review
- Sedentary lifestyle is independently associated with higher fat mass index regardless of physical activity level in patients with coronary artery disease.BMC cardiovascular disorders · 2025Article
- Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy.EMBO molecular medicine · 2025Article
- Effects of statins on serum sCD40, sCD146 and PAPP-An in patients with coronary heart disease.Journal of medical biochemistry · 2025Article
- Article
- Identification of effect modifiers using a stratified Mendelian randomization algorithmic framework.European journal of epidemiology · 2025Article
- Implantable Biosensors for Vascular Diseases: Directions for the Next Generation of Active Diagnostic and Therapeutic Medical Device Technologies.Biosensors · 2025Review
- Mapping the knowledge of omics in myocardial infarction: A scientometric analysis in R Studio, VOSviewer, Citespace, and SciMAT.Medicine · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery disease (CAD) is the leading cause of death and disability worldwide, and its prevalence is expected to increase in the coming years. CAD events are caused by the interplay of genetic and environmental factors, the effects of which are mainly mediated through cardiovascular risk factors. The techniques used to study the genetic basis of these diseases have evolved from linkage studies to candidate gene studies and genome-wide association studies. Linkage studies have been able to identify genetic variants associated with monogenic diseases, whereas genome-wide association studies have been more successful in determining genetic variants associated with complex diseases. Currently, genome-wide association studies have identified approximately 40 loci that explain 6% of the heritability of CAD. The application of this knowledge to clinical practice is challenging, but can be achieved using various strategies, such as genetic variants to identify new therapeutic targets, personal genetic information to improve disease risk prediction, and pharmacogenomics. The main aim of this narrative review is to provide a general overview of our current understanding of the genetics of coronary artery disease and its potential clinical utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.