ArticleeLife2014
Escherichia coli swimming is robust against variations in flagellar number.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 90 citations in OpenAlex.
- Flagellar location determines the stability of bacterial surface entrapment.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bacteria Optimize Tumble Bias to Strategically Navigate Surface Constraints.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Coinfecting phages impede each other's entry into the cell.Current biology : CB · 2024Article
- Positioning of cellular components by the ParA/MinD family of ATPases.Current opinion in microbiology · 2024Review
- Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network.Scientific reports · 2023Article
- Optical traps induce fluorophore photobleaching by two-photon excitation.Biophysical journal · 2023Article
- σeLife · 2023Article
- Evasion of toll-like receptor recognition byFrontiers in microbiology · 2023Article
- The Chemoreceptor Sensory Adaptation System Produces Coordinated Reversals of the Flagellar Motors on an Escherichia coli Cell.Journal of bacteriology · 2022Article
- Steady-state running rate sets the speed and accuracy of accumulation of swimming bacteria.Biophysical journal · 2022Article
- Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.Nature communications · 2022Article
- Serial passage in an insect host indicates genetic stability of the human probioticEvolution, medicine, and public health · 2022Article
- Multiple functions of flagellar motility and chemotaxis in bacterial physiology.FEMS microbiology reviews · 2021Review
- Upcoming flow promotes the bundle formation of bacterial flagella.Biophysical journal · 2021Article
- Production and Characterization of Motile and Chemotactic Bacterial Minicells.ACS synthetic biology · 2021Article
- Direct Mapping from Intracellular Chemotaxis Signaling to Single-Cell Swimming Behavior.Biophysical journal · 2020Article
- ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS.Molecular cell · 2020Article
- Fluctuations in Intracellular CheY-P Concentration Coordinate Reversals of Flagellar Motors inBiomolecules · 2020Article
- A Multi-Scale Approach to ModelingEntropy (Basel, Switzerland) · 2020Article
- Manipulating rod-shaped bacteria with optical tweezers.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial chemotaxis is a paradigm for how environmental signals modulate cellular behavior. Although the network underlying this process has been studied extensively, we do not yet have an end-to-end understanding of chemotaxis. Specifically, how the rotational states of a cell's flagella cooperatively determine whether the cell 'runs' or 'tumbles' remains poorly characterized. Here, we measure the swimming behavior of individual E. coli cells while simultaneously detecting the rotational states of each flagellum. We find that a simple mathematical expression relates the cell's run/tumble bias to the number and average rotational state of its flagella. However, due to inter-flagellar correlations, an 'effective number' of flagella-smaller than the actual number-enters into this relation. Data from a chemotaxis mutant and stochastic modeling suggest that fluctuations of the regulator CheY-P are the source of flagellar correlations. A consequence of inter-flagellar correlations is that run/tumble behavior is only weakly dependent on number of flagella. DOI: http://dx.doi.org/10.7554/eLife.01916.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.