ArticleeLife2014
Endogenous RNA interference is driven by copy number.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Pervasive formation of double-stranded RNAs by overlapping sense/antisense transcripts in budding yeast mitosis and meiosis.RNA (New York, N.Y.) · 2025Article
- Epigenetic inheritance of gene silencing is maintained by a self-tuning mechanism based on resource competition.Cell systems · 2023Article
- Stimulation of adaptive gene amplification by origin firing under replication fork constraint.Nucleic acids research · 2022Article
- Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis.Microorganisms · 2020Review
- A copy number variant is associated with a spectrum of pigmentation patterns in the rock pigeon (Columba livia).PLoS genetics · 2020Article
- Protocols for Northern Analysis of Exosome Substrates and Other Noncoding RNAs.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Transcription-induced formation of extrachromosomal DNA during yeast ageing.PLoS biology · 2019Article
- Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome.Life science alliance · 2019Article
- Article
- An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells.Cell stem cell · 2017Article
- Environmental change drives accelerated adaptation through stimulated copy number variation.PLoS biology · 2017Article
- TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells.Genome biology · 2016Article
- A System for Dosage-Based Functional Genomics in Poplar.The Plant cell · 2015Article
- Annual meeting of the EpiGeneSys Network of Excellence--Advancing epigenetics towards systems biology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A plethora of non-protein coding RNAs are produced throughout eukaryotic genomes, many of which are transcribed antisense to protein-coding genes and could potentially instigate RNA interference (RNAi) responses. Here we have used a synthetic RNAi system to show that gene copy number is a key factor controlling RNAi for transcripts from endogenous loci, since transcripts from multi-copy loci form double stranded RNA more efficiently than transcripts from equivalently expressed single-copy loci. Selectivity towards transcripts from high-copy DNA is therefore an emergent property of a minimal RNAi system. The ability of RNAi to selectively degrade transcripts from high-copy loci would allow suppression of newly emerging transposable elements, but such a surveillance system requires transcription. We show that low-level genome-wide pervasive transcription is sufficient to instigate RNAi, and propose that pervasive transcription is part of a defense mechanism capable of directing a sequence-independent RNAi response against transposable elements amplifying within the genome. DOI: http://dx.doi.org/10.7554/eLife.01581.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.