ArticleeLife2014
Automated quantitative histology reveals vascular morphodynamics during Arabidopsis hypocotyl secondary growth.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- An AINTEGUMENTA phosphoswitch controls bilateral stem cell activity during secondary growth.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A gain-of-function mutation in BnaIAA13 disrupts vascular tissue and lateral root development in Brassica napus.Journal of experimental botany · 2024Article
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- Using positional information to provide context for biological image analysis with MorphoGraphX 2.0.eLife · 2022Article
- The BOP-type co-transcriptional regulator NODULE ROOT1 promotes stem secondary growth of the tropical Cannabaceae tree Parasponia andersonii.The Plant journal : for cell and molecular biology · 2021Article
- Phloem exudate metabolic content reflects the response to water-deficit stress in pea plants (Pisum sativum L.).The Plant journal : for cell and molecular biology · 2021Article
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- Peptide Signaling Pathways in Vascular Differentiation.Plant physiology · 2020Review
- Versatile method for quantifying and analyzing morphological differences in experimentally obtained images.Plant signaling & behavior · 2020Article
- A simple mathematical model of allometric exponential growth describes the early three-dimensional growth dynamics of secondary xylem in Arabidopsis roots.Royal Society open science · 2019Article
- Bifacial cambium stem cells generate xylem and phloem during radial plant growth.Development (Cambridge, England) · 2019Article
- Plant Vascular Tissues-Connecting Tissue Comes in All Shapes.Plants (Basel, Switzerland) · 2018Review
- Micro Imaging Displays the Sucrose Landscape within and along Its Allocation Pathways.Plant physiology · 2018Article
- Bifacial stem cell niches in fish and plants.Current opinion in genetics & development · 2017Review
- Analysis of 3D Cellular Organization of Fixed Plant Tissues Using a User-guided Platform for Image Segmentation.Bio-protocol · 2017Article
- Precision Automation of Cell Type Classification and Sub-Cellular Fluorescence Quantification from Laser Scanning Confocal Images.Frontiers in plant science · 2016Article
- Vascular Cambium Development.The arabidopsis book · 2015Article
- Omics and modelling approaches for understanding regulation of asymmetric cell divisions in arabidopsis and other angiosperm plants.Annals of botany · 2014Review
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among various advantages, their small size makes model organisms preferred subjects of investigation. Yet, even in model systems detailed analysis of numerous developmental processes at cellular level is severely hampered by their scale. For instance, secondary growth of Arabidopsis hypocotyls creates a radial pattern of highly specialized tissues that comprises several thousand cells starting from a few dozen. This dynamic process is difficult to follow because of its scale and because it can only be investigated invasively, precluding comprehensive understanding of the cell proliferation, differentiation, and patterning events involved. To overcome such limitation, we established an automated quantitative histology approach. We acquired hypocotyl cross-sections from tiled high-resolution images and extracted their information content using custom high-throughput image processing and segmentation. Coupled with automated cell type recognition through machine learning, we could establish a cellular resolution atlas that reveals vascular morphodynamics during secondary growth, for example equidistant phloem pole formation. DOI: http://dx.doi.org/10.7554/eLife.01567.001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.