ArticleReproductive sciences (Thousand Oaks, Calif.)2014
Biocompatibility of a sonicated silk gel for cervical injection during pregnancy: in vivo and in vitro study.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent Trends in Tissue Engineering Strategies for Uterine Endometrial Regeneration: a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2026Pooled it
- Tissue Engineering for Cervical Function in Pregnancy.Current opinion in biomedical engineering · 2022Article
- Next generation strategies for preventing preterm birth.Advanced drug delivery reviews · 2021Review
- Cervical Augmentation with an Injectable Silk-Based Gel: Biocompatibility in a Rat Model of Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Injectable Silk-Based Hydrogel as an Alternative to Cervical Cerclage: A Rabbit Study.Tissue engineering. Part A · 2020Article
- Ex vivo pregnant-like tissue model to assess injectable hydrogel for preterm birth prevention.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Silk fibroin safety in the eye: a review that highlights a concern.BMJ open ophthalmology · 2020Review
- Prevention of preterm birth: Novel interventions for the cervix.Seminars in perinatology · 2017Review
- Shape Memory Silk Protein Sponges for Minimally Invasive Tissue Regeneration.Advanced healthcare materials · 2017Article
- [Application of silk-based tissue engineering scaffold for tendon / ligament regeneration].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Injectable silk-based biomaterials for cervical tissue augmentation: an in vitro study.American journal of obstetrics and gynecology · 2016Article
- In vivo bioresponses to silk proteins.Biomaterials · 2015Review
- Innovative methods of cervical assessment and potential for novel treatment.Clinical obstetrics and gynecology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo evaluate the biocompatibility of silk gel for cervical injection. STUDY
designSilk gel was injected into the cervix of pregnant rats on day 13 (n = 11) and harvested at day 17. Histology of silk gel was compared with suture controls. Also, human cervical fibroblasts were cultured on silk gel and tissue culture plastic (TCP) in vitro. Cell viability, proliferation, metabolic activity, gene expression (COL1A1, COL3A1, and COX2), and release of proinflammatory mediators (interleukin [IL] 6 and IL-8) were evaluated.
resultsIn vivo, a mild foreign body response was seen surrounding the silk gel and suture controls. In vitro, cervical fibroblasts were viable, metabolically active, and proliferating at 72 hours. Release of IL-6 and IL-8 was similar on silk gel and TCP. Collagen and COX2 gene expression was similar or slightly decreased compared with TCP.
conclusionsSilk gel was well tolerated in vivo and in vitro, which supports continuing efforts to develop silk gels as an alternative to cervical cerclage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.