ArticleElectrophoresis2014
Characterization of goat milk lactoferrin N-glycans and comparison with the N-glycomes of human and bovine milk.
Article in Electrophoresis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 84 citations in OpenAlex.
- Human Milk as a Model for Next-Generation Infant Formula: Opportunities and Challenges.Advances in nutrition (Bethesda, Md.) · 2026Review
- Optimizing Lactoferrin Isolation for Functional and Structural Integrity: A Molecular Insight.Molecules (Basel, Switzerland) · 2026Review
- The Effect of the Season on the Time Dependent Changes in Colostrum Lactoferrin Level in Murciano-Granadina Goats in Intensive System Farming.Animals : an open access journal from MDPI · 2024Article
- Label-Free Liquid Chromatography-Mass Spectrometry Quantitation of RelativeInternational journal of molecular sciences · 2024Article
- The Multifaceted Roles of Bovine Lactoferrin: Molecular Structure, Isolation Methods, Analytical Characteristics, and Biological Properties.Journal of agricultural and food chemistry · 2023Review
- Isolation and characterization of bioactive lactoferrin from camel milk by novel pH-dependent method for large scale production.Biotechnology reports (Amsterdam, Netherlands) · 2022Article
- Lactoferrin Decreases EnterotoxigenicPharmaceutics · 2022Article
- Recent Insights Into Processing Approaches and Potential Health Benefits of Goat Milk and Its Products: A Review.Frontiers in nutrition · 2021Review
- The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro.Signal transduction and targeted therapy · 2020Article
- Polymorphism of lactoferrin gene in Egyptian goats and its association with milk composition traits in Zaraibi breed.Tropical animal health and production · 2020Article
- Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action.Biomolecules · 2020Review
- Evaluation of Milk Colostrum Derived Lactoferrin of Sahiwal (International journal of molecular sciences · 2019Article
- Thoroughbred mare's milk exhibits a unique and diverse free oligosaccharide profile.FEBS open bio · 2018Article
- Dietary N-Glycans from Bovine Lactoferrin and TLR Modulation.Molecular nutrition & food research · 2018Article
- Studying Lactoferrin N-Glycosylation.International journal of molecular sciences · 2017Review
- Characterization of recombinant human lactoferrin N-glycans expressed in the milk of transgenic cows.PloS one · 2017Article
- Oligosaccharides Released from Milk Glycoproteins Are Selective Growth Substrates for Infant-Associated Bifidobacteria.Applied and environmental microbiology · 2016Article
- Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions.Molecules (Basel, Switzerland) · 2015Review
- The impact of the milk glycobiome on the neonate gut microbiota.Annual review of animal biosciences · 2015Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Numerous milk components, such as lactoferrin, are recognized as health-promoting compounds. A growing body of evidence suggests that glycans could mediate lactoferrin's bioactivity. Goat milk lactoferrin is a candidate for infant formula supplementation because of its high homology with its human counterpart. The aim of this study was to characterize the glycosylation pattern of goat milk lactoferrin. After the protein was isolated from milk by affinity chromatography, N-glycans were enzymatically released and a complete characterization of glycan composition was carried out by advanced MS. The glycosylation of goat milk lactoferrin was compared with that of human and bovine milk glycoproteins. Nano-LC-Chip-Q-TOF MS data identified 65 structures, including high mannose, hybrid, and complex N-glycans. Among the N-glycan compositions, 37% were sialylated and 34% were fucosylated. The results demonstrated the existence of similar glycans in human and goat milk but also identified novel glycans in goat milk that were not present in human milk. These data suggest that goat milk could be a source of bioactive compounds, including lactoferrin that could be used as functional ingredients for food products beneficial to human nutrition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.