ArticleElectrophoresis2014
Hydrolysis of milk gangliosides by infant-gut associated bifidobacteria determined by microfluidic chips and high-resolution mass spectrometry.
Article in Electrophoresis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- The physiological characteristics and applications of sialic acid.NPJ science of food · 2025Review
- Engineered plants provide a photosynthetic platform for the production of diverse human milk oligosaccharides.Nature food · 2024Article
- Bioactive Functions of Lipids in the Milk Fat Globule Membrane: A Comprehensive Review.Foods (Basel, Switzerland) · 2023Review
- Gut Microbial Sialidases and Their Role in the Metabolism of Human Milk Sialylated Glycans.International journal of molecular sciences · 2023Review
- The role of human milk fats in shaping neonatal development and the early life gut microbiota.Microbiome research reports · 2023Review
- Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health.Frontiers in nutrition · 2021Review
- The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being.Nutrients · 2020Review
- Thoroughbred mare's milk exhibits a unique and diverse free oligosaccharide profile.FEBS open bio · 2018Article
- Milk Glycans and Their Interaction with the Infant-Gut Microbiota.Annual review of food science and technology · 2018Review
- Utilization of Host-Derived Glycans by IntestinalFrontiers in microbiology · 2018Review
- Bovine dairy complex lipids improve in vitro measures of small intestinal epithelial barrier integrity.PloS one · 2018Article
- Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development.Frontiers in pediatrics · 2018Review
- Identification of Oligosaccharides in Feces of Breast-fed Infants and Their Correlation with the Gut Microbial Community.Molecular & cellular proteomics : MCP · 2016Article
- Oligosaccharides Released from Milk Glycoproteins Are Selective Growth Substrates for Infant-Associated Bifidobacteria.Applied and environmental microbiology · 2016Article
- Detection of sialic acid-utilising bacteria in a caecal community batch culture using RNA-based stable isotope probing.Nutrients · 2015Article
- Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut.Pediatric research · 2015Review
- The impact of the milk glycobiome on the neonate gut microbiota.Annual review of animal biosciences · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Gangliosides are receiving considerable attention because they participate in diverse biological processes. Milk gangliosides appear to block pathogen adhesion and modify the intestinal ecology of newborns. However, the interaction of milk gangliosides with gut bifidobacteria has been little investigated. The digestion products of a mixture of gangliosides isolated from milk following incubation with six strains of bifidobacteria were studied using nanoHPLC Chip Q-TOF MS. To understand ganglioside catabolism in vitro, the two major milk gangliosides--GM3 and GD3--remaining in the media after incubation with bifidobacteria were quantified. Individual gangliosides were identified through postprocessing precursor ion scans, and quantitated with the "find by molecular feature" algorithm of MassHunter Qualitative Analysis software. Bifidobacterium infantis and B. bifidum substantially degraded the GM3 and GD3, whereas B. longum subsp. longum and B. animalis subsp. lactis only showed moderate degradation. MALDI FTICR MS analysis enabled a deeper investigation of the degradation and identified ganglioside degradation specifically at the outer portions of the glycan molecules. These results indicate that certain infant gut-associated bifidobacteria have the ability to degrade milk gangliosides releasing sialic acid, and that these glycolipids could play a prebiotic role in the infant gut.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.