ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2014
Asystole immediately following intravenous fat emulsion for overdose.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effectiveness of treatments for propranolol toxicity: a systematic review of current approaches and evidence.European journal of clinical pharmacology · 2026Pooled it
- Practical guide for the management of systemic toxicity caused by local anesthetics.Journal of anesthesia · 2019Guideline
- Lipid emulsion for xenobiotic overdose: PRO.British journal of clinical pharmacology · 2023Article
- Intravenous lipid emulsion for the treatment of poisonings in 313 dogs and 100 cats (2016-2020).Frontiers in veterinary science · 2023Article
- Successful Management of Severe Bupropion Toxicity with Lipid Emulsion Therapy: A Complex Case Report and Literature Review.European journal of case reports in internal medicine · 2023Article
- Massive metoprolol overdose requiring ECMO: brief review of the evidence behind recommended treatments.BMJ case reports · 2021Review
- Parenteral Nutrition and Cardiotoxicity.Cardiovascular toxicology · 2021Review
- Intravenous Fat Emulsion Does Not Significantly Alter Clotting Markers in Dabigatran-Treated Blood.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- The Use of Extracorporeal Life Support in a Patient Suffering from Venlafaxine Intoxication. A Case Report.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2020Article
- Use of a Porcine Model to Evaluate the Risks and Benefits of Vasopressors in Propranolol Poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020Article
- Pharmacological and mechanical management of calcium channel blocker toxicity.BMJ case reports · 2018Article
- Awake caudal anaesthesia in neonates/young infants for improved patient safety.BMJ case reports · 2017Article
- Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults.Critical care medicine · 2017Article
- In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2016Article
- The possible role of intravenous lipid emulsion in the treatment of chemical warfare agent poisoning.Toxicology reports · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Use of intravenous fat emulsion (IFE) for the treatment of poisoned patients in extremis is increasing. Little literature exists describing failures and complications of IFE. We describe two cardiac arrests temporally associated with IFE. A 50-year-old woman presented after ingesting 80 total tablets of metoprolol 25 mg and bupropion 150 mg. Bradycardia and hypotension were refractory to calcium salts, catecholamines, and high dose insulin (HDI). With a pulse of 40/min and mean arterial pressure (MAP) of 30 mmHg, 100 mL of 20 % IFE was given; within 30 s, brady-asystolic arrest occurred. Pulses returned after 3 min of CPR. The patient died on hospital day 4 of multisystem organ failure (MSOF). A 53-year-old man presented after ingesting of 3,600 mg of diltiazem and 1,200 mg of propranolol. Bradycardia and hypotension were refractory to calcium salts, catecholamines, HDI, bicarbonate, and atropine. With a pulse of 30/min and a MAP of 40 mmHg, 150 mL of 20 % IFE was given; within 1 min, a brady-asystolic arrest occurred. Pulses returned after 6 min of CPR. The patient died on hospital day 7 of MSOF. Reported cases of IFE failures or potential complications are sparse. This report adds only case experience, not clarity. We report two cardiac arrests that were temporally associated with IFE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.