ArticleInvestigative ophthalmology & visual science2014
Structural and biochemical analyses of choroidal thickness in human donor eyes.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 85 citations in OpenAlex.
- Choroidal Vascular Findings in a Case of Multifocal Geographic Atrophy: A Clinicopathologic Correlation.Investigative ophthalmology & visual science · 2026Article
- Deep learning-based automated classification of choroidal layers in en face swept-source optical coherence tomography images.BMC ophthalmology · 2025Article
- Finite Element Model of the Effect of Optic Nerve Sheath Anisotropy on Ocular Loading During Horizontal Duction.Bioengineering (Basel, Switzerland) · 2025Article
- Role of Serine Protease Inhibitors A1 and A3 in Ocular Pathologies.Investigative ophthalmology & visual science · 2024Review
- Integrity of the Hyperreflective Layer in the Inner Choroid in Eyes with Drusen.Ophthalmology and therapy · 2024Article
- Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration.Human molecular genetics · 2023Article
- Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells.Cells · 2022Article
- The Essential Role of the Choriocapillaris in Vision: Novel Insights from Imaging and Molecular Biology.Annual review of vision science · 2022Review
- One-year efficacy of "rescue photodynamic therapy" for patients with typical age-related macular degeneration, polypoidal choroidal vasculopathy, and pachychoroid neovasculopathy refractory to anti-vascular endothelial growth factor therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG.International journal of molecular sciences · 2022Article
- Phytochemical‑rich herbal formula ATG‑125 protects against sucrose‑induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice.Molecular medicine reports · 2022Article
- Automated segmentation of choroidal layers from 3-dimensional macular optical coherence tomography scans.Journal of neuroscience methods · 2021Article
- Review
- Effects of age and binarising area on choroidal vascularity index in healthy eyes: an optical coherence tomography study.International ophthalmology · 2021Article
- Relationship between vascular densities of choriocapillaris and the whole choroid using OCTA.International ophthalmology · 2020Article
- Haller's vessels patterns in non-neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.Microvascular research · 2020Article
- Normal aging changes in the choroidal angioarchitecture of the macula.Scientific reports · 2020Article
- Features of the Choroidal Structures in Myopic Children Based on Image Binarization of Optical Coherence Tomography.Investigative ophthalmology & visual science · 2020Article
- Visualization of Mouse Choroidal and Retinal Vasculature Using Fluorescent Tomato Lectin Perfusion.Translational vision science & technology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe choroid plays a vital role in the health of the outer retina. While measurements of choroid using optical coherence tomography show altered thickness in aging and macular disease, detailed histopathologic and proteomic analyses are lacking. In this study we sought to evaluate biochemical differences in human donor eyes between very thin and thick choroids.
methodsOne hundred forty-one eyes from 104 donors (mean age ± standard deviation, 81.5 ± 12.2) were studied. Macular sections were collected, and the distance between Bruch's membrane and the inner surface of the sclera was measured in control, early/dry age-related macular degeneration (AMD), neovascular AMD, and geographic atrophy eyes. Proteins from the RPE-choroid of eyes with thick and thin choroids were analyzed using two-dimensional electrophoresis and/or mass spectrometry. Two proteins with altered abundance were confirmed using Western blot analysis.
resultsDonor eyes showed a normal distribution of thicknesses. Eyes with geographic atrophy had significantly thinner choroids than age-matched controls or early AMD eyes. Proteomic analysis showed higher levels of the serine protease SERPINA3 in thick choroids and increased levels of tissue inhibitor of metalloproteinases-3 (TIMP3) in thin choroids.
conclusionsConsistent with clinical imaging observations, geographic atrophy was associated with choroidal thinning. Biochemical data suggest an alteration in the balance between proteases and protease inhibitors in eyes that lie at the extremes of choroidal thickness. An improved understanding of the basic mechanisms associated with choroidal thinning may guide the development of new therapies for AMD.
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