ArticleMedical & biological engineering & computing2014
Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model.
Article in Medical & biological engineering & computing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Impact of different 3D regions of interest on quantifying dynamic lumbar vertebral microstructure in ovariectomized rats-a micro-CT study.Frontiers in medicine · 2024Article
- Mechanoregulated trabecular bone adaptation: Progress report onBiomaterials and biosystems · 2022Review
- A novel percutaneous crossed screws fixation in treatment of Day type II crescent fracture-dislocation: A finite element analysis.Journal of orthopaedic translation · 2020Article
- A novel technique with reduced computed tomography exposure to predict vertebral compression fracture: a finite element study based on rat vertebrae.Medical & biological engineering & computing · 2019Article
- Analysis of microscopic bone properties in an osteoporotic sheep model: a combined biomechanics, FE and ToF-SIMS study.Journal of the Royal Society, Interface · 2019Article
- Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.Stem cells translational medicine · 2018Article
- Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test.Applied bionics and biomechanics · 2017Article
- Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats.Histochemistry and cell biology · 2015Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For assessing mechanical properties of osteoporotic bone, biomechanical testing combined with in silico modeling plays a key role. The present study focuses on microscopic mechanical bone properties in a rat model of postmenopausal osteoporosis. Female Sprague-Dawley rats were (1) euthanized without prior interventions, (2) sham-operated, and (3) subjected to ovariectomy combined with a multi-deficiencies diet. Rat vertebrae (corpora vertebrae) were imaged by micro-CT, their stiffness was determined by compression tests, and load-induced stress states as well as property changes due to the treatment were analyzed by finite-element modeling. By comparing vertebra stiffness measurements with finite-element calculations of stiffness, an overall microscopic Young's modulus of the bone was determined. Macroscopic vertebra stiffness as well as the microscopic modulus diminish with progression of osteoporosis by about 70 %. After strong initial changes of bone morphology, further decrease in macroscopic stiffness is largely due to decreasing microscopic Young's modulus. The micromechanical stress calculations reveal particularly loaded vertebra regions prone to failure. Osteoporosis-induced changes of the microscopic Young's modulus alter the fracture behavior of bone, may influence bone remodeling, and should be considered in the design of implant materials.
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