ArticleToxicology and applied pharmacology2014
Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice.
Article in Toxicology and applied pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.Particle and fibre toxicology · 2022Pooled it
- Effects of mineral fibres in an in vitro placental syncytiotrophoblast model.Current research in toxicology · 2025Article
- Effects of different amosite preparations on macrophages, lung damages, and autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2024Article
- Global geological occurrence and character of the carcinogenic zeolite mineral, erionite: A review.Frontiers in chemistry · 2022Review
- Mitogen signal-associated pathways, energy metabolism regulation, and mediation of tumor immunogenicity play essential roles in the cellular response of malignant pleural mesotheliomas to platinum-based treatment: a retrospective study.Translational lung cancer research · 2021Article
- Enhanced morphological transformation of human lung epithelial cells by continuous exposure to cellulose nanocrystals.Chemosphere · 2020Article
- Metabolic rewiring and redox alterations in malignant pleural mesothelioma.British journal of cancer · 2020Review
- Detection of Erionite and Other Zeolite Fibers in Soil by the Fluidized Bed Preparation Methodology.Microscope (Carshalton Beeches (Surrey)) · 2019Article
- Analysis of autoantibody profiles in two asbestiform fiber exposure cohorts.Journal of toxicology and environmental health. Part A · 2018Article
- Emerging Role of Immunosuppression in Diseases Induced by Micro- and Nano-Particles: Time to Revisit the Exclusive Inflammatory Scenario.Frontiers in immunology · 2018Review
- Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis.Molecular cancer · 2016Review
- Silica, Silicosis, and Autoimmunity.Frontiers in immunology · 2016Review
- Selective inhibitory effects of 50-nm gold nanoparticles on mouse macrophage and spleen cells.Journal of immunotoxicology · 2016Article
- A Deep Look Into Erionite Fibres: an Electron Microscopy Investigation of their Self-Assembly.Scientific reports · 2015Article
- Differential Susceptibility of Human Pleural and Peritoneal Mesothelial Cells to Asbestos Exposure.Journal of cellular biochemistry · 2015Article
- Current Research and Opportunities to Address Environmental Asbestos Exposures.Environmental health perspectives · 2015Article
- Article
- Autoimmune markers for progression of Libby amphibole lamellar pleural thickening.Inhalation toxicologyArticle
- Amphibole asbestos as an environmental trigger for systemic autoimmune diseases.Autoimmunity reviewsReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundErionite has similar chemical and physical properties to amphibole asbestos, which induces autoantibodies in mice. Current exposures are occurring in North Dakota due to the use of erionite-contaminated gravel. While erionite is known to cause mesothelioma and other diseases associated with asbestos, there is little known about its effects on the immune system.
objectivesWe performed this study to determine whether erionite evokes autoimmune reactions in mice.
methodsBone marrow derived macrophages (BMDM) were used to measure toxicity induced by erionite. Cytokine production by BMDM and splenocytes of C57BL/6 mice was examined by bead arrays and ELISA following exposure to erionite, amphiboles and chrysotile. Wild type C57BL/6 mice were exposed to saline, erionite, amphibole asbestos (Libby 6-Mix) or chrysotile through intratracheal instillations at equal mass (60μg/mouse). Seven months after exposure, sera were examined for anti-nuclear antibodies (ANA) and IL-17. Immunohistochemistry was used to detect immune complex deposition in the kidneys.
resultsErionite and tremolite caused increased cytokine production belonging to the TH17 profile including IL-17, IL-6, TGF-β, and TNF-α. The frequency of ANA was increased in mice treated with erionite or amphibole compared to saline-treated mice. IL-17 and TNF-α were elevated in the sera of mice treated with erionite. The frequency of immune complex deposition in the kidneys increased from 33% in saline-treated mice to 90% with erionite.
conclusionsThese data demonstrate that both erionite and amphibole asbestos induce autoimmune responses in mice, suggesting a potential for adverse effects in exposed communities.
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