Evidence map›Paper›PMID 24518796›Full record

ArticleJournal of clinical gastroenterology2014

Early microbial markers of celiac disease.

Liisa Viitasalo, Laura Niemi, Merja Ashorn, Sara Ashorn, Jonathan Braun, Heini Huhtala, Pekka Collin, Markku Mäki, Katri Kaukinen, Kalle Kurppa and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  8. A Case of Chronic Cough in a Winemaker.Respiratory medicine case reports · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Liisa Viitasalo*Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital §School of Health Sciences ¶School of Medicine, University of Tampere Departments of †Pediatrics ∥Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital #Seinäjoki Central Hospital, Seinäjoki **Hämeenlinna Central Hospital, Hämeenlinna, Finland ‡Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
Laura Niemi
Merja Ashorn
Sara Ashorn
Jonathan Braun
Heini Huhtala
Pekka Collin
Markku Mäki
Katri Kaukinen
Kalle Kurppa
Sari Iltanen
Tampere University · FITampere University · FIPediatrics and Genetics · USSeinäjoki University of Applied Sciences · FITampere University Hospital · FI

Funding

Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
NIDDK NIH HHS DK 46763NIDDK NIH HHS P01 DK046763NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

background and goalsSeroreactivity against the Saccharomyces cerevisiae (ASCA), Pseudomonas fluorescens-associated sequence (I2), and Bacteroides caccae TonB-linked outer membrane protein (OmpW) has been detected in celiac disease patients with small-bowel mucosal atrophy. Levels of these antibodies decrease during a gluten-free diet, but their functions and time of appearance in celiac disease are not known. We aimed to search for evidence of possible microbial targets of the immune responses in the early-stage celiac disease patients who showed normal small-bowel mucosal architecture at the time of the first investigations, but later on a gluten-containing diet developed mucosal atrophy. MATERIALS AND

methodsForty-four cases with proven early-stage celiac disease and normal mucosal morphology were enrolled. Patients' sera were tested for celiac disease antibodies against tissue transglutaminase (tTG-ab), endomysium, and for microbial antibodies against I2, OmpW, and ASCA IgG and IgA isotypes in both at the time of diagnosis and while on a gluten-free diet.

resultsThirty-four (77%) of 44 patients with early-stage celiac disease had elevated serum antibodies to one or more of the antibodies ASCA, I2, and OmpW. Furthermore, 5 of 6 cases negative for both tTG-ab and endomysium showed positivity for the microbial markers. Seroreactivity to ASCA IgA, ASCA IgG, and OmpW decreased significantly during gluten-free diet.

conclusionsSeroreactivity to different microbial antigens is evident already in patients with early-stage celiac disease. ASCA antibodies seem to be gluten-dependent. The results indicate that the microbial targets might have a role in the early development of celiac disease.

Indexed as

AdolescentAdultAgedAntibodies, BacterialAntibodies, FungalBacterial Outer Membrane ProteinsBiomarkersCeliac DiseaseDiet, Gluten-FreeFemaleGTP-Binding ProteinsHumansImmunoglobulin AImmunoglobulin GMaleMiddle AgedAntibodies, BacterialAntibodies, FungalBacterial Outer Membrane ProteinsBiomarkersGTP-Binding ProteinsImmunoglobulin AImmunoglobulin GOmpW protein, Bacteroides caccaePfiT protein, Pseudomonas fluorescensProtein Glutamine gamma Glutamyltransferase 2Saccharomyces cerevisiae ProteinsSuperantigensTransglutaminases

Identifiers

PMID24518796
PMCPMC4082475
OpenAlexW2326796041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.